서울대학교 약학대학 제약학과 학사
서울대학교 대학원 약학과 약학석사(생약학전공)
서울대학교 대학원 약학과 약학박사(생약학전공)
2004 – 2007: Research Associate, College of Pharmacy, The Ohio State University
2007 – 2008: Research Scientist, College of Pharmacy, The Ohio State University
2009 – 2010: Senior Researcher, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
2010 – 2014: Assistant Professor, College of Pharmacy, Dongguk University
2014 – 2019: Associate Professor, College of Pharmacy, Dongguk University
2019 – present: Associate Professor, College of Pharmacy, Seoul National University
- 대사질환 조절 및 염증 조절 천연물 유래 화합물 발굴
- 천연물유래 신규 이차대사산물 발굴
- Prenylated flavonoids from the roots and rhizomes of Sophora tonkinensis and their effects on the expression of inflammatory mediators and proprotein convertase subtilisin/kexin type 9. J Nat Prod, 2019, 82, 309-317
- Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network. Sci Rep, 2018, 8, 6737
- Chemical constituents with proprotein convertase subtilisin/kexin type 9 mRNA expression inhibitory activity from dried immature Morus alba fruits. J Agric Food Chem, 2017, 65, 5316-5321
- SKI3301, a purified herbal extract from Sophora tonkinensis, inhibited airway inflammation and bronchospasm in allergic asthma animal models in vivo. J Ethnopharmacol, 2017, 206, 298-305
- Isoliquiritigenin ameliorates dextran sulphate sodium-induced colitis through the inhibition of MAPK pathway. Int Immunopharmacol, 2016, 31, 223-232
This lab focuses on the discovery of pharmacologically active natural products using bioactivity-guided separation from domestic and foreign plant materials. Two main target s are proprotein convertase subtilisin/kexin type 9 (PCSK9) and inflammasomes. Using PCSK9 target, we are interested in discovering PCSK9 synthesis inhibitors or PCSK9-LDLR binding inhibitors which may give potential therapeutic effects in lowering cholesterol levels in blood. By using screening method based on inflammasome-mediated inflammation, we aim to find out naturally occurring molecules which may relieve or treat the symptoms of inflammatory bowel diseases.
