학력
Ph,D, Department of Medicinal Chemistry, State University of New York at Buffalo
주요경력
1991-1995 : Postdoc. National Cancer Institute, NIH
1995-1999 : Assistant Professor, College of Pharmacy, SNU
1999-2005 : Associate Professor, College of Pharmacy, SNU
2005-present : Professor, College of Pharmacy, SNU
주요관심 연구분야
- Protein Kinase C Ligand 기전의 항암제 연구
- Vanilloid Receptor Ligand 기전의 진통제 연구
- Aminoacyl-tRNA Synthetase Inhibitor 기전의 항생제 연구
- Anti-amyloid Ligand 기전의 치매 예방 치료제연구
대표논문자료
- Kang DW, Kim YS, Lim KS, Kim MS, Pearce LV, Pavlyukovets VA, Tao AK, Lang-Kuhs KA, Blumberg PM, Lee J, Halogenation of 4-Hydroxy/Amino-3-methoxyphenyl Acetamide TRPV1 Agonists Showed Enhanced Antagonism to Capsaicin. BIOORGANIC & MEDI CINAL CHEMISTRY 18(22), pp. 8092-8105 (2010.11)
- Kang JH, Kim Y, Won SH, Park SK, Lee CW, Kim HM, Lewin NE, Perry NA, Pearce LV, Lundberg DJ, Surawski RJ, Blumberg PM, Lee J, Polar 3-alkylidene-5- pivaloyloxymethyl-5′-hydroxymethyl-gamma-lactones as Protein Kinase C ligands and Antitumor Agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(3), pp. 1008-1012 (2010.02)
- Farhanullah R, Kang T , Yoon EJ, Choi EC, Kim S, Lee J, 2-[2-Substituted-3-(3,4-dichlo -robenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. European Journal of Medicinal Chemistry 44(1), pp. 239-250 (2009.01)
- Choi HK, Choi S, Lee Y, Kang DW, Ryu H, Maeng HJ, Chung SJ, Pavlyukovets VA, Pearce LV, Toth A, Tran R, Wang Y, Morgan MA, Blumberg PM, Lee J, Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Bioorganic & Medicinal Chemistry 17(2), pp. 690-698 (2009.01)
- HyungChul Ryu, Mi-Kyoung Jin, Sang-Uk Kang, Su Yeon Kim, Dong Wook Kang, Jeewoo Lee,* Larry V. Pearce, Vladimir A. Pavlyukovets, Matthew A. Morgan, Richard Tran, Attila Toth, Daniel J. Lundberg, and Peter M. Blumberg, Stereospecific High-affinity TRPV1 Antagonists: Chiral N-(2-Benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino) phenyl]propionamide Analogues. JOURNAL OF MEDICINAL CHEMISTRY 51(1), pp. 57-67 (2008.01)
- Duan, D.; Sigano, D. M.; Kelley, J. A.; Lai, C. C.; Lewin, N. E.; Kedei, N.; Peach, M. L.; Lee, J.; Abeyweera, T. P.; Rotenberg, S. A.; Kim, H.; Kim, Y. H.; Kazzouli, S. E.; Chung, J-U.; Young, H. A.; Young, M. R.; Baker, A.; Colburn, N. H.; Haimovitz-Friedman, A.; Truman, J-P.; Parrish, D. A.; Deschamps, J. R.; Perry, N. A.; Surawski, R. J.; Blumberg, P. M.; Marquez, V. E., Conformationally constrained analogues of diacylglycerol. 29. cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective iological activities. JOURNAL OF MEDICINAL CHEMISTRY 51(17), pp. 5198-5220 (2008.09)
- Kang, D. W.; Ryu, H.; Lee, J.; Krystle A. Lang, K. A.; Pavlyukovets, V. A.; Pearce, L. A.; Ikeda, T.; Lazar, J.; Blumberg, P. M.Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin. Bioorganic & Medicinal Chemistry Letters 17, pp. 214-219 (2007)
- Chung, J-U.; Kim, S. Y.; Lim, J-O.; Choi, H-K, Kang, S-U.; Yoon, H-S.; Ryu, H.; Kang, D. W.; Lee, J.; Kang, B.; Choi, S.; Toth, A.; Pearce, L. V.; Pavlyukovets, V. A.; Lundberg, D. J.; Blumberg, P. M. Alpha-Substituted N-(4-tert-butylbenzyl)-N’-[4-(methylsulfonyl -amino)-benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 15, pp. 6043-6053 (2007)
관심연구분야
연구실 Fax
888-0649
