학력
2017년 서울대학교 분자의학 및 바이오제약학 (박사)
2012년 서울대학교 동물생명공학 (학사)
주요경력
2022년 – 현재 : 서울대학교 약학대학 약학과, 조교수
2021년 – 2022년 : Novartis Institutes for Biomedical Research, Principal Scientist
2018년 – 2021년 : La Jolla Institute for Immunology, Postdoctoral Fellow
2017년 – 2018년 : 서울대학교 종합약학연구소, 연수연구원
주요관심 연구분야
- 항암면역치료제 개발을 위한 암 면역학 연구
- 고형암 치료를 위한 CAR-T/TCR-T 개발 연구
- 암환경에 노출된 면역세포의 Epigenetics, Transcriptional networking 연구
- 크리스퍼, 바이러스벡터 등의 유전자 교정 툴을 활용한 바이오 의약품 연구
- 다양한 질병에 노출된 면역세포의 유전정보 분석을 통한 새로운 신약 타겟 발굴
대표논문자료
- Anticoagulation therapy promotes the tumor immune-microenvironment and potentiates the efficacy of immunotherapy by alleviating hypoxia, J Immunother Cancer 2021
- BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells, Nature Immunology 2021
- Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses, Vaccines 2020
- GITR agonism triggers antitumor immune responses through IL21-expressing follicular helper T cells, Cancer Immunol Res. 2020
- Differentiation of c‐Kit+CD24+ natural killer cells into myeloid cells in a GATA‐2‐dependent manner, FASEB J. 2020
- Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection. Front Immunol. 2019
- Paradoxical association of TET loss of function with genome-wide DNA hypomethylation. Proc Natl Acad Sci U S A 2019
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion, Proc Natl Acad Sci U S A 2019
- GM-CSF promotes antitumor immunity by inducing Th9 cell responses, Cancer Immunol Res 2019
- NR4A transcription factors limit CAR T cell function in solid tumours, Nature 2019
- Activation of NKT cells in an anti-PD-1-resistant tumor model enhances anti-tumor immunity by reinvigorating exhausted CD8 T cells, Cancer Res 2018
- IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours, Nature Commun 2017
- Tumor-derived osteopontin suppresses antitumor immunity by promoting extramedullary myelopoiesis., Cancer Res. 2014
- Serum amyloid A3 exacerbates cancer by enhancing the suppressive capacity of myeloid‐derived suppressor cells via TLR2‐dependent STAT3 activation., Eur J Immunol. 2014
- Enhanced antitumor immunotherapeutic effect of B-cell-based vaccine transduced with modified adenoviral vector containing type 35 fiber structures., Gene Ther. 2014
