연구실소개
시스템약물학 연구실 연구 분야
- 빅데이터(big omics data) 기반 신약 타겟 발굴 및 인공지능을 이용한 신약개발 모델 연구
- 동물대체 약물학 모델 개발을 위한 질병 및 독성발현경로 연구
- 지속가능형 화장품 소재 연구
교육경력
Ph.D. Biological Engineering Division, Massachusetts Institute of Technology (MIT)
M.S. College of Pharmacy, Seoul National University
B.S. College of Pharmacy, Seoul National University
학술활동
2017.1 – 현재, 사단법인 한국응용약물학회 편집위원장 (Editor-in-Chief, Biomolecules & Therapeutics, 2018 SCI IF 3.08)
2017.1 – 현재, 한국동물실험대체법학회 부회장
2010.1 – 현재, 대한피부장벽학회 재무이사
2015.1 – 2016.12, 한국동물실험대체법학회 간사장
2013.1 – 2018.12, 사단법인 대한약학회 국제협력위원회 간사
2010.1 – 2012.12, 사단법인 대한약학회 총무간사
2010.1 – 2012.12, 사단법인 한국에프디시법제학회 학술위원장
2009.1 – 2016.12, 사단법인 한국응용약물학회 편집간사, 편집 부위원장
대표연구업적
- Keratinocyte-derived IL-36gamma plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019, doi: 10.1007/s00204-019-02506-6 (교신저자)
- A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019, 93, 1903-1915 (교신저자)
- 2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore. Bioorg Med Chem. 2019, 27(13), 2948-2958 (교신저자)
- Adiponectin secretion-promoting phenylethylchromones from the agarwood of Aquilaria malaccensis. J. Nat. Prod., 2019, 82, 259-264 (교신저자)
- Kojyl cinnamate esters are peroxisome proliferator-activated receptor α/γ dual agonists. Bioorg Med Chem. 2018, 26(21), 5654-5663 (교신저자)
- Leptin regulates the pro-inflammatory response in human epidermal keratinocytes. Arch Dermatol Res. 2018, 310(4), 351-362 (교신저자)
- 2-Formyl-komarovicine promotes adiponectin production in human mesenchymal stem cells through PPARγ partial agonism. Bioorg Med Chem. 2018, 26(5), 1069-1075 (교신저자)
- Phosphodiesterase 4B plays a role in benzophenone-3-induced phototoxicity in normal human keratinocytes. Toxicol Appl Pharmacol. 2018, 338, 174-181 (교신저자)
- Polypharmacology of N6‑(3-Iodobenzyl)adenosine-5′‑N‑methyluronamide (IB-MECA) and related A3 adenosine receptor ligands: peroxisome proliferator activated receptor (PPAR) γ partial agonist and PPARδ antagonist activity suggests their antidiabetic potential. J Med Chem. 2017, 60, 7459-7475 (교신저자)
- Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016, 310, 185-194 (교신저자)
- Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor. Toxicol Appl Pharmacol. 2015, 283(2): 147-155 (교신저자)
- Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors. Toxicol Appl Pharmacol. 2014, 280(2):199-206 (교신저자)
- Retinoic acid and hydroquinone induce inverse expression patterns on cornified envelope-associated proteins; implication in skin irritation. J. Dermatol. Sci. 2014, 76: 112-119 (교신저자)
- Human melanocytes form a PAX3-expressing melanocyte cluster on Matrigel by the cell migration process. J Dermatol Sci. 2014, 76:60-66. (교신저자)
- Kojyl cinnamate ester derivatives promote adiponectin production during adipogenesis in human adipose tissue-derived mesenchymal stem cells. Bioorg Med Chem Lett. 2014 24(9):2141-2145. (교신저자)
- Neuronal development genes are key elements mediating the reinforcing effects of methamphetamine, amphetamine and methylphenidate. Psychopharmacology 2013, 230: 399-413 (교신저자).
- The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells. Bioorg. Med. Chem. Lett. 2013. 23: 3237-3276 (교신저자).
- Interleukin-4 inhibits the melanogenesis of normal human melanocytes through the JAK2-STAT6 signaling pathway. J. Invest. Dermatol. 2013, 133(2): 528-536 (교신저자).
- Tensile stimuli increase nerve growth factor in human dermal fibroblasts independent of tension-induced TGFβ production. Exp. Dermatol. 2013, 22(1):72-74 (교신저자)
- Kojic acid-induced IL-6 production in human keratinocytes plays a role in its anti-melanogenic activity in skin. J. Dermatol. Sci. 2012, 66(3):207-215. (교신저자)
- Interleukin-17A increases leptin production in human bone marrow mesenchymal stem cells. Biochem. Pharmacol. 2012, 83:661-670. (교신저자).
- The retinoic acid-induced up-regulation of insulin-like growth factor 1 and 2 is associated with prolidase-dependent collagen synthesis in UVA-irradiated human dermal equivalents. J. Dermatol. Sci. 2012, 66: 51-59. (교신저자).
- A resource for discovering specific and universal biomarkers for distributed stem cells. PLoS One 2011, 6(7):e22077 (제1저자).
- Asian dust storm particles induce a broad toxicological transcriptional program in human epidermal keratinocytes. Toxicol. Lett. 2011. 200: 92-99. (교신저자).
- Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. Biochem. Pharmacol. 2010, 80: 95-103. (교신저자).
- MAP17 is associated with the T helper cell cytokine induced down-regulation of filaggrin transcription in human keratinocytes. Exp. Dermatol. 2010, 19: 355-362. (교신저자).
- IL-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes. Biochem. Pharmacol. 2009, 77: 1835-1844. (교신저자).
- (-)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPARgamma transactivation. Biochem. Pharmacol. 2009, 77: 125-133 (교신저자).
