학력
2005.8 – 2011.8 : Department of Biochemistry & Molecular Genetics, College of Medicine, University of Illinois at Chicago, 박사
1999.3 – 2001.2 : 서울대학교 대학원 약학과, 석사
1995.3 – 1999.2 : 서울대학교 약학대학 약학과, 학사
주요경력
2023.3 – 현재 : 서울대학교 약학대학 약학과, 부교수
2013.9 – 2023.2 : 아주대학교 약학대학 약학과, 조교수-부교수
2012.1 – 2013.7 : Genentech, Inc. Translational Oncology, 박사후 연구원
2011.5 – 2011.12 : Department of Biochemistry & Molecular Genetics, College of Medicine, University of Illinois at Chicago, 박사후 연구원
2001.3 – 2005.8 : 삼성생명과학연구소, 연구원
주요관심 연구분야
- 진화독성학 기반 암 및 대사질환 발생 기전 연구
- 암 및 대사질환의 예방과 치료를 위한 혁신 신약 표적 발굴 및 검증
- 암종별 암대사 특이성 규명 및 암미세환경과 암대사 동시 표적 혁신 항암 전략 연구
- 혁신 신약 표적 활성 측정/스크리닝 플랫폼 개발 및 이를 활용한 유효물질 도출
주요논문
- Blaha CS*, Ramakrishnan G*, Jeon, SM*#, Nogueira V*, Rho H, Kang S, Bhaskar P, Terry AR, Aissa AF, Frolov MV, Patra KC, Robey RB, Hay N#. A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Nat Commun 13, 899 (2022). (*co-first author, #co-corresponding author)
- Singh A*, Daemen A*, Nickles D*, Jeon SM*, Foreman O, Sudini K, Gnad F, Lajoie S, Gour N, Mitzner W, Chatterjee S, Choi EJ, Ravishankar B, Rappaport A, Patil N, McCleland M, Johnson L, Acquaah-Mensah G, Gabrielson E, Biswal S, Hatzivassiliou G. NRF2 activation promotes aggressive lung cancer and associates with poor clinical outcomes. Clin. Cancer Res. 2021;27:877–88 (* equal contribution)
- Choi YJ*, Jeon SM*, Shin S. Impact of a Ketogenic Diet on Metabolic Parameters in Patients with Obesity or Overweight and with or without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials. Nutrients. 2020 Jul 6;12(7):2005. (* equal contribution)
- Nguyen TTM, An YJ, Cha JW, Ko YJ, Lee H, Chung CH, Jeon SM, Lee J, Park S. Real-Time In-Organism NMR Metabolomics Reveals Different Roles of AMP-Activated Protein Kinase Catalytic Subunits. Anal Chem. 2020 Jun 2;92(11):7382-7387.
- Shin S, Jung HJ, Jeon SM, Park YJ, Chae JW, Yun HY. Vancomycin Dosage and Its Association with Clinical Outcomes in Pediatric Patients with Gram-Positive Bacterial Infections. Risk Manag Healthc Policy. 2020 Jun 29;13:685-695.
- Choi EJ, Jeon SM. NRF2-driven redox metabolism takes a center stage in cancer metabolism from an outside-in perspective. Arch Pharm Res. 2020 Mar 04;43:321–336
- Brown P; RELISH Consortium, Zhou Y. Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database (Oxford). 2019 Jan 1;2019:baz085.
- Ju C*, Jeon SM*, Jun HS, Moon CK. Diol-ginsenosides from Korean Red Ginseng delay the development of type 1 diabetes in diabetes-prone biobreeding rats. J Ginseng Res. 2019 June (online) (* co-first author)
- Ham IH, Oh HJ, Jin H, Bae CA, Jeon SM, Choi KS, Son SY, Han SU, Brekken RA, Lee D, Hur H. Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer. Mol Cancer. 2019 Mar 30;18(1):68.
- Noh Y, Jeon SM, Shin S. Association between glucose-lowering treatment and cancer metastasis among patients with preexisting type 2 diabetes and incident malignancy. Int J Cancer. 2019 Apr 1;144(7):1530-1539.
- Jeon SM*, Hay N*. Expanding the concepts of cancer metabolism. Exp Mol Med. 2018 Apr 16;50(4):32. (* corresponding author)
- Jeon SM*, Shin AE. Exploring vitamin D metabolism and function in cancer. Exp Mol Med. 2018 Apr 16;50(4):20. (* corresponding author)
- Kim S, Lee E, Jung J, Lee JW, Kim HJ, Kim J, Yoo JH, Lee HJ, Chae SY, Jeon SM, Son BH, Gong GY, Sharan S, Chang S. microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer. Oncogene. 2018 Mar 12.
- Kim SR, Song JH, Ahn JH, Lee GS, Ahn H, Yoon SI, Kang SG, Kim PH, Jeon SM, Choi EJ, Shin S, Cha Y, Cho S, Kim DE, Chang SY, Ko HJ. Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation. Antiviral Res. 2018 Feb 1;151:87-96.
- DeWaal D, Nogueira V, Terry AR, Patra KC, Jeon SM, Guzman G, Au J, Long CP, Antoniewicz MR, Hay N. Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nat Commun. 2018 Jan 31;9(1):446.
- Jung BJ, Yoo HS, Shin S, Park YJ, Jeon SM. Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities. Biomol Ther (Seoul). 2018 Jan 1;26(1):57-68
- Choi EJ, Jung BJ, Lee SH, Yoo HS, Shin EA, Ko HJ, Chang S, Kim SY, Jeon SM. A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer. Oncogene. 2017 Sep 14;36(37):5285-5295.
- Hong EH, Heo EY, Song HJ, Kwon BE, Lee JY, Park Y, Kim J, Chang SY, Chin YW, Jeon SM*, Ko HJ*. Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells. Oncotarget. 2017, April 24. (* corresponding author)
- Kim N, Yim HY, He N, Lee CJ, Kim JH, Choi JS, Lee HS, Kim S, Jeong E, Song M, Jeon SM, Kim WY, Mills GB, Cho YY, Yoon S. Cardiac glycosides display selective efficacy for STK11 mutant lung cancer. Sci Rep. 2016 Jul 19;6:29721.
- Jeon SM. Regulation and Function of AMPK in Physiology and Diseases. Exp Mol Med. 2016 Jul 15;48(7):e245.
- Kwon BE, Song JH, Song HH, Kang JW, Hwang SN, Rhee KJ, Shim A, Hong EH, Kim YJ, Jeon SM, Chang SY, Kim DE, Cho S, Ko HJ. Antiviral activity of oroxylin A against Coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice. Plos One. 2016 May 19;11(5):e0155784
- Wang Q, Yu WN, Chen X, Peng XD, Jeon SM, Birnbaum M, Guzman G, Hay N. Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms. Cancer Cell. 2016, Apr 11; 29(4):523-535.
- Jeon SM*, Hay N. The double-edged sword of AMPK signaling in cancer and its therapeutic implications. Arch Pharm Res. 2015 Mar 1;38(3):346-57. (* corresponding author)
- Jeon SM*, Hay N. The dark face of AMPK as an essential tumor promoter. Cell Logist. 2012 Oct 1;2(4):197-202. (* corresponding author)
- Jeon SM, Chandel N, Hay N. AMPK regulates NADPH homeostasis to promote tumor cell survival during energy stress. Nature. 2012 May 31; 485, 661–665.
