Education
Ph.D. in Pharmacy at Seoul National University (2017)
Department of Molecular Medicine and Biopharmaceutical Sciences
B.S. in Animal Biotechnology at Seoul National University (2012)
Department of Animal and Food Biotechnology
Career
Assistant Professor: Seoul National University College of Pharmacy, Seoul, Republic of Korea (2022- Current)
Principal Scientist: Novartis Institutes for Biomed Research, Inc. MA, USA (2021-2022)
Postdoctoral Fellow: La Jolla Institute for Immunology (LJI) CA, USA (2018-2021)
Postdoctoral Fellow, Research Institute of Pharmaceutical Science,
Seoul National University, Seoul, Republic of Korea (2017-2018)
Research Field
- Immuno-Oncology research to develop Cutting Edge Biopharmaceutical medicine
- Epigenetics or Transcriptional networks of TILs
- Next-generation CAR/TCR-T cell, Engineered Cytokine, and Antibody therapy developments
- Genome editing using CRISPR, Virus vector, and nuclease
- Bioinformatic Analysis to understand the molecular mechanism underlying immune cell dysfunction or screen a new target for a new drug
Representative Publication
- Anticoagulation therapy promotes the tumor immune-microenvironment and potentiates the efficacy of immunotherapy by alleviating hypoxia, J Immunother Cancer 2021
- BATF and IRF4 cooperate to counter exhaustion in tumour-infiltrating CAR T cells, Nature Immunology 2021
- Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses, Vaccines 2020
- GITR agonism triggers antitumor immune responses through IL21-expressing follicular helper T cells, Cancer Immunol Res. 2020
- Differentiation of c‐Kit+CD24+ natural killer cells into myeloid cells in a GATA‐2‐dependent manner, FASEB J. 2020
- Monocyte-Derived Dendritic Cells Dictate the Memory Differentiation of CD8+ T Cells During Acute Infection. Front Immunol. 2019
- Paradoxical association of TET loss of function with genome-wide DNA hypomethylation. Proc Natl Acad Sci U S A 2019
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion, Proc Natl Acad Sci U S A 2019
- GM-CSF promotes antitumor immunity by inducing Th9 cell responses, Cancer Immunol Res 2019
- NR4A transcription factors limit CAR T cell function in solid tumours, Nature 2019
- Activation of NKT cells in an anti-PD-1-resistant tumor model enhances anti-tumor immunity by reinvigorating exhausted CD8 T cells, Cancer Res 2018
- IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours, Nature Commun 2017
- Tumor-derived osteopontin suppresses antitumor immunity by promoting extramedullary myelopoiesis., Cancer Res. 2014
- Serum amyloid A3 exacerbates cancer by enhancing the suppressive capacity of myeloid‐derived suppressor cells via TLR2‐dependent STAT3 activation., Eur J Immunol. 2014
- Enhanced antitumor immunotherapeutic effect of B-cell-based vaccine transduced with modified adenoviral vector containing type 35 fiber structures., Gene Ther. 2014
