Education
2001 – 2006 : Ph.D. Marine Natural Products Chemistry, Scripps Institution of Oceanography, University of California-San Diego
1996 – 1998 : M.S. Marine Chemistry, Dept. Oceanography, Seoul National University
1992 – 1996 : B.S. Oceanography (Minor in Chemistry), Dept. Oceanography, College of Natural Sciences, Seoul National University
Career
2019 – present : Director, Natural Products Research Institute, Seoul National University
2012 – 2017 : Howard Hughes Medical Institute, International Early Career Scientist
2009 – present : Assistant, Associate, Full Professor, College of Pharmacy, Seoul National University
2008 – 2009 : Harvard Medical School, Instructor
2006 – 2008 : Harvard Medical School, Postdoctoral Research Fellow
1998 – 2001 : Republic of Korea Navy (Retired Lieutenant Junior Grade)
Research Field
– Metabologenomics-based logical natural product discovery
– Structure elucidation of new natural products
– Natural product chemical biology
– Bioinformatic analysis of biosynthetic genes for natural products
– Drug discovery based on microbial natural products
– Structure elucidation of new natural products
– Natural product chemical biology
– Bioinformatic analysis of biosynthetic genes for natural products
– Drug discovery based on microbial natural products
Representative Publication
- “Discovery of terminal oxazole-bearing natural products by a targeted metabologenomic approach” Park, J.; Shin, Y.-H.; Hwang, S.; Kim, J.; Moon, D. H.; Kang, I.; Ko, Y.-J.; Chung, B.; Nam, H.; Kim, S.; Moon, K.; Oh, K.-B.; Cho, J.-C.; Lee, S. K.; Oh, D.-C.* Angewandte Chemie International Edition, 2024, 63, e202402465.
- “Exploring the diverse landscape of biaryl-containing peptides generated by cytochrome P450 macrocyclases” Nam, H.; An, J. S.; Lee, J.; Lee, H.; Park, H.; Oh, K.-B.; Oh, D.-C.*; Kim, S.* Journal of the American Chemical Society, 2023, 145, 22047-22057.
- “Targeted and logical discovery of piperazic acid-bearing natural products based on genomic and spectroscopic signatures” Shin, D.; Byun, W. S.; Kang, S.; Kang, I.; Bae, E. S.; An, J. S.; Im, J. H.; Park, J.; Kim, E.; Ko, K.; Hwang, S.; Lee, H.; Kwon, Y.; Ko, Y.-J.; Hong, S.; Nam, S.-J.; Kim, S. B.; Fenical, W.; Yoon, Y. J.; Cho, J.-C.; Lee, S. K.*; Oh, D.-C.* Journal of the American Chemical Society, 2023, 145, 19676-19690.
- “Discovery and biosynthesis of cihunamides, macrocyclic antibacterial RiPPs with a unique C-N linkage formed by CYP450 catalysis” An, J. S.; Lee, H.; Kim, H.; Woo, S.; Nam, H.; Lee, J.; Lee, J. Y.; Nam, S.-J.; Lee, S. K.; Oh, K.-B.; Kim, S.*; Oh, D.-C.* Angewandte Chemie International Edition, 2023, 62, e202300998.
- “Genomic and spectroscopic signature-based discovery of natural macrolactams” Shin, Y.-H.; Im, J. H.; Kang, I.; Kim, E.; Jang, S. C.; Cho, E.; Shin, D.; Hwang, S.; Du, Y. E.; Huynh, T.-H.; Ko, K.; Ko, Y.-J.; Nam, S.-J.; Awakawa, T.; Lee, J.; Hong, S.; Abe, I.; Moore, B. S.; Fenical, W.; Yoon, Y. J.; Cho, J.-C.; Lee, S. K.; Oh, K.-B.; Oh, D.-C.* Journal of the American Chemical Society, 2023, 145, 1886-1896.
- “Unprecedented noncanonical features of the nonlinear nonribosomal peptide synthetase assembly line for WS9326A biosynthesis” Kim, M.-S.; Bae, M.; Jung, Y.-E.; Kim, J. M.; Hwang, S.; Song, M. C.; Ban, Y. H.; Bae, E. S.; Hong, S.; Lee, S. K.; Cha, S.-S.*; Oh, D.-C.*; Yoon, Y. J.* Angewandte Chemie International Edition, 2021, 60, 19766-19773.
- “Rhizolutin, a novel 7/10/6-tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer’s disease” Kwon, Y.; Shin, J.; Nam, K.; An, J. S.; Yang, S.-H.; Hong, S.-H.; Bae, M.; Moon, K.; Cho, Y.; Woo, J.; Park, K.; Kim, K.; Shin, J.; Kim, B.-Y.; Kim, Y.*; Oh, D.-C.* Angewandte Chemie International Edition, 2020, 59, 22994-22998.
- “Structural revision of lydiamycin A by reinvestigation of the stereochemistry” Hwang, S.; Shin, D.; Kim, T. H.; An, J. S.; Jo, S.-I.; Jang, J.; Hong, S.; Shin, J.; Oh, D.-C.* Organic Letters, 2020, 22, 3855-3859.
- “Structures and biosynthetic pathway of pulvomycins B-D, 22-membered macrolides from an estuarine Streptomyces sp.” Moon, K.; Cui, J.; Kim, E.; Riandi, E. S; Park, S. H.; Byun, W. S.; Kal, Y.; Park, J. Y.; Hwang, S.; Shin, D.; Sun, J.; Oh, K.-B.; Cha, S.; Shin, J.; Lee, S. K.; Yoon, Y. J.; Oh, D.-C.* Organic Letters, 2020, 22, 5358-5362.
- “Donghaesulfins A and B, dimeric benz[a]anthracene thioethers from volcanic island-derived Streptomyces sp.” Bae, M.; An, J. S.; Bae, E. S.; Oh, J.; Park, S. H.; Lim, Y.; Ban, Y. H.; Kwon, Y.; Cho, J.-C.; Yoon, Y. J.; Lee, S. K.; Shin, J.; Oh, D.-C.* Organic Letters, 2019, 21, 3635-3639.
