Education
Ph.D. University of Minnesota (1992)
M.S. Seoul National University (1987)
B.S. Seoul National University (1985)
Career
2005-present Seoul National University, Associate Professor
2000-2005 University of Sejong, Assistant/Associate Professor
1996-2000 University of Yonsei, Collage of medicine Assistant Professor
Research Field
- Mechanism of transcriptional activation of nuclear receptors in lipid metabolism
- Nuclear receptors in vascular remodeling
- Estrogen receptors in breast cancer development
- Screening and development of nuclear receptor selective ligands
Representative Publication
- Kim JY, Han YH, Nam MW, Kim HJ, Lee MO. RORα suppresses interleukin-6-mediated hepatic acute phase response. Sci Rep. 2019 Aug 13;9(1):11798.
- Han YH, Shin KO, Kim JY, Khadka DB, Kim HJ, Lee YM, Cho WJ, Cha JY, Lee BJ, Lee MO. A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis. J Clin Invest. 2019 Mar 11;130:1684-1698.
- Lee MH, Koh D, Na H, Ka NL, Kim S, Kim HJ, Hong S, Shin YK, Seong JK, Lee MO. MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells. Autophagy. 2018;14(5):812-824.
- Kim HJ, Han YH, Na H, Kim JY, Kim T, Kim HJ, Shin C, Lee JW, Lee MO. Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction. Sci Rep. 2017 Nov 22;7:16041.
- Ka NL, Na TY, Lee MO. NR1D1 enhances oxidative DNA damage by inhibiting PARP1 activity. Mol Cell Endocrinol. 2017 Oct 15;454:87-92.
- Han YH, Kim HJ, Na H, Nam MW, Kim JY, Kim JS, Koo SH, Lee MO. RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis. Cell Rep. 2017 Jul 5;20:124-135.
- Ka NL, Na TY, Na H, Lee MH, Park HS, Hwang S, Kim IY, Seong JK, Lee MO. NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer. Cancer Res. 2017 May 1;77:2453-2463.
- Na TY, Kim GH, Oh HJ, Lee MH, Han YH, Kim KT, Kim JS, Kim DD, Lee MO. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci Rep. 2017 Mar 7;7:43823.
- Na H, Lee H, Lee MH, Lim HJ, Kim HJ, Jeon Y, Kang HL, Lee MO. Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis. Life Sci. 2016 Dec 1;166:13-19.
- Na TY, Ka NL, Rhee H, Kyeong D, Kim MH, Seong JK, Park YN, Lee MO. Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma. Oncogene. 2016 Oct 13;35(41):5435-5445.
- Han YH, Kim DK, Na TY, Ka NL, Choi HS, Lee MO. ROR alpha switches transcriptional mode of ERR gamma that results in transcriptional repression of CYP2E1 under ethanol-exposure. Nucleic Acids Res. 2016 Feb 18;44(3):1095-104.
- Na TY, Han YH, Ka NL, Park HS, Kang YP, Kwon SW, Lee BH, Lee MO. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. J Pathol. 2015 Apr;235(5):710-20.
- Kim EJ, Choi YK, Han YH, Kim HJ, Lee IK, Lee MO. RORα suppresses proliferation of vascular smooth muscle cells through activation of AMP-activated protein kinase. Int J Cardiol. 2014 Aug 20;175(3):515-21.
- Han YH, Kim HJ, Kim EJ, Kim KS, Hong S, Park HG, Lee MO. RORα decreases oxidative stress through the induction of SOD2 and GPx1 expressions and thereby protects from non-alcoholic steatohepatitis in mice. Antioxid Redox Signal.2014 Nov 20;21(15):2083-94.
- Kang HJ, Lee MH, Kang HL, Kim SH, Ahn JR, Na H, Na TY, Kim Y, Seong JK, Lee MO. Differential Regulation of Estrogen Receptor α Expression in Breast Cancer Cells by Metastasis-Associated Protein 1. Cancer Res. 2014 Mar 1;74(5):1484-94.
