1982-86: BS, Seoul National University
(College of Agriculture, Dept. of Agricultural Chemistry)
1986-88: MS, Seoul National University
(College of Agriculture, Dept. of Agricultural Chemistry)
1992-95: MS, Univ. of Tennessee at Knoxville, TN, USA
(Dept. of Biochemistry)
1996-2000: Ph.D. Univ. of North Carolina @ Chapel Hill, NC, USA
(Dept. of Pharmacology, Dr. Rudy. L. Juliano)
2013.03 – Current : Professor, SNU College of Pharmacy
2021.01 – Current : Fellow (Medical Sciences) The Korean Academy of Science and Technology
2016.05 – Current : Member, Seoul National University Institutional Biosafety Committee
2015.08 – 2021.07 : Vice director, SNU Research Institute of Pharmaceutical Sciences
2011.07 – 2013.07 : Chairperson, Department of Pharmacy, SNU
2010.11 – 2020.12 : Associate Member (Medical Sciences) The Korean Academy of Science and Technology
2009.09 – 2013.02 : Assistant/Associate Professor, SNU College of Pharmacy
2001.11 – 2009.08 : Assistant/Associate Professor, SNU College of Medicine
2001.01 – 2001.10 : Research Fellow, Memorial Sloan-Kettering Cancer Center, USA
- Nature of TM4SF5-mediated regulation of immune response during NAFLD and HCC
- Study on TM4SF5-dependent immuno-metabolic regulation in non-alcholoic fatty (metabolic) liver disease
- Study on clinical relevance of TM4SF5 to liver diseases
- Investigation of TM4SF5 gene-engineered (TG and KO) animal models
- Mechanistic regulation of TM4SF5 as an immune checkpoint for immune exhaustion
- Development of diagnostic platforms for TM4SF5-dependent liver diseases
- Development of anti-TM4SF5 reagents against liver diseases: anti-NASH, fibrosis, or tumor small compound or antibody?
- Please refer http://jwl.snu.ac.kr/
- E Kim*, H Um*, J Park*, JW Jung, JE Kim, H Lee, E-A Shin, Y Pinanga, H Lee, SH Nam, and Lee JW (Corresponding author). TM4SF5-dependent crosstalk between hepatocytes and macrophages reprograms the inflammatory environment during NAFLD. Cell Reports. Accepted. 2021
- HE Song*, Y Lee*, E Kim*, CY Cho, O Jung, D Lee, EG Lee, SH Nam, M Kang, S JY Macalino, JE Kim, JW Jung, SW Kwon, S Choi& and Lee JW& (Co-corresponding author) N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application. Theranostics. 2021. 11(16):8092-8111.
- Ryu J*, Kim EM*, Kang M-K, Song D-G, Shin E-A, H Lee, Jung JW, Nam SH, Kim JE, Kim H-J, Son T, Kim S, Kim HY and Lee JW (Co-corresponding author). Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression. Journal of Pathology. 2021. 253(1):55-67.
- JW Jung, SJY. Macalino, M Cui, JE Kim, H-J Kim, D-G Song, SH Nam, S Kim, Sun Choi, and Lee JW (Cocorresponding authors). Transmembrane 4 L six family member 5 senses arginine for mTORC1 signaling. Cell Metabolism. 2019. 29(6):1306-1319.
- Nam, SH, Kim, D, Lee, D, Rhu J, Lee, H-M, Song, D-G, Jung, JW. Kim, JE, Kim, H-J, Kwon, NH, Jo,E-K, Kim, S, and Lee JW (Corresponding author). Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis. Journal of Clinical Investigation, 2018. 128(11):5034-5055.
- H-M Ahn, J Ryu, JM Song, Y Lee, H-J Kim, I Choi, SJ Kim, Lee JW, (Co-corresponding author) and S Kim. Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity. Theranostics. 2017. 7(3): 594 -613.
- D Lee, J Na*, J Ryu*, H-J Kim*, SH Nam*, M Kang, JW Jung, M-S Lee, HE Song, J Choi, G-H Lee, TY Kim, J-K Chung, KH Park, S-H Kim, H Kim, HW Seo, P Kim, H Youn, and Lee JW (Corresponding author). Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocellular carcinoma cells. Hepatology. 2015. 61(6):1978-1997.
- Lee SA, Ryu HW, Kim YM, Choi S, Lee MJ, Kwak TK, Kim HJ, Cho M, Park KH, Lee JW. Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative. Hepatology. 2009. 49(4):1316-25.
- Choi S, Lee SA, Kwak TK, Kim HJ, Lee MJ, Ye SK, Kim SH, Kim S, Lee JW. Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. Blood. 2009. 113(8):1845-55.
- Lee SA, Lee SY, Cho IH, Oh MA, Kang ES, Kim YB, Seo WD, Choi S, Nam JO, Tamamori-Adachi M, Kitajima S, Ye SK, Kim S, Hwang YJ, Kim IS, Park KH, Lee JW. Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. J Clin Invest. 2008. 118(4):1354-66.
