Education
- 2003: Ph.D., University of Texas at Austin
- 1994: Master of Pharmacy, Graduate School of Pharmacy, Seoul National University (Specialization: Pharmaceutical Chemistry)
- 1992: Bachelor of Pharmacy, College of Pharmacy, Seoul National University, Department of Pharmaceutical Sciences
Career
- 2021 – Present: Professor, College of Pharmacy, Seoul National University
- 2016 – 2021: Associate Professor, College of Pharmacy, Seoul National University
- 2012 – 2016: Assistant Professor, College of Pharmacy, Seoul National University
- 2010 – 2012: Assistant Professor, College of Pharmacy, Ajou University
- 2004 – 2010: Postdoctoral Researcher, Pennsylvania State University
Research Field
- Development of mechanistic probes and modulators to elucidate the functions and mechanisms of proteins at the molecular level
- Development of novel fluorescent probe compounds and biosensors
- Development of photosensitizers and the control of cell death using light
Representative Publication
- Le Bich Hang Pham, Khanh Linh Chung, Seoyoung Kim, Jeeyeon Lee*, Multifunctional photosensitizers for the activation and visualization of pyroptotic cell death under photodynamic therapy, Sensors and Actuators: B. Chemical (2024), 134799.
- Yun-Jeong Kim, Bumhee Lim, Seo Young Kim, Yoon-Ze Shin, Nayoung Yu, Eun-Kyung Shin, Jae-Eon Lee, Yong Hyun Jeon, Dae-Duk Kim, Jeeyeon Lee*, Hyuk-Jin Cha*, Remodeling of sorafenib as an orally bioavailable ferroptosis inducer for Lung Cancer by chemical modification of adenine-binding motif, Biomed Pharmacother, 2024 May 25:176:116758.
- Ho Jin Lee, Phuong Chi Pham, Honglan Pei, Bumhee Lim, Seung Yeob Hyun, Byungyeob Baek, Byungjin Kim, Yunha Kim, Min-Hwan Kim, Nae-Won Kang, Hye-Young Min, Dae-Duk Kim, Jeeyeon Lee*, Ho-Young Lee*, Development of the phenylpyrazolo[3,4-d]pyrimidine-based, insulin-like growth factor receptor/Src/AXL-targeting small molecule kinase inhibitor, Theranostics, 11(4):1918-1936 (2021).
- Jaehyun Park, Bumhee Lim, Na Keum Lee, Ji Hye Lee, Kyungkuk Jang, San Won Kang, Suzi Kim, Ikyon Kim, Hyonseok Hwang, Jeeyeon Lee*, Dual-functioning IQ-LVs as lysosomal viscosity probes with red-shifted emission and inhibitors of autophagic flux, Sensors and Actuators: B. Chemical, 309:127764 (2020).
- Lim B, Baek B, Jang K, Lee NK, Lee JH, Lee Y, Kim J, Kang SW, Park J, Kim S, Kang N, Hong S, Kim D, Kim I, Hwang H, Lee J* Novel turn-on fluorescent biosensors for selective detection of cellular Fe3+ in lysosomes: thiophene as a selectivity-tuning handle for Fe3+ sensors, Dyes and Pigments, 169:51-59 (2019).
- Kwon S, Lee Y, Jung Y, Kim JH, Baek B, Lim B, Lee J, Kim I, Lee J* Mitochondria-targeting indolizino[3,2-c]quinolines as novel class of photosensitizers for photodynamic anticancer activity, Eur. J. Med. Chem., 148:116-127 (2018).
- Lee HJ, Pham PC, Hyun SY, Baek B, Kim B, Kim Y, Min HY, Lee J*, Lee HY* Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity, Molecular Cancer, 17(1):50 (2018).
- Kwon S, Kwon DI, Jung Y, Kim JH, Lee Y, Lim B, Kim I, Lee J* Indolizino[3,2-c]quinolines as environment-sensitive fluorescent light-up probes for targeted live cell imaging, Sensors & Actuators: B. Chemical, 252:340-352 (2017).
- Lee J, Lee Y, Park SJ, Lee J, Kim YS, Suh YG, Lee J*, Discovery of highly selective and potent monoamine oxidase B inhibitors: Contribution of additional phenyl rings introduced into 2-aryl-1,3,4-oxadiazin-5(6H)-one, J. Med. Chem., 130:365-378 (2017).
- Lee R, Gam J, Moon J, Lee SG, Suh YG, Lee BG, Lee J* A critical element of the light-induced quaternary structural changes in YtvA-LOV, Protein Science 24(12):1997-2007 (2015).
- Park S, Kwon DI, Lee J*, Kim I.* When Indolizine Meets Quinoline: Diversity-Oriented Synthesis of New Polyheterocycles and Their Optical Properties, ACS Comb. Sci, 17(8):459-69 (2015) (selected as the cover article).
- Moon J, Gam J, Lee SG, Suh YG, and Lee J* Light Regulated Tetracycline Binding to the Tet Repressor, –Eur. J, 20: 2508-2514 (2014).
