Research Field
1. The insulin-like growth factor receptor/insulin receptor and insulin-like growth factor binding proteins in carcinogenesis
2. Role of microenvironment in cancer development and metastatic progression
3. Tumor microenvironmental regulation of drug resistance in anticancer therapy
4. Development of effective personalized anticancer therapy
5. Screening natural products and development of novel cancer chemopreventive strategy
Representative Publication
- Kim JH, Choi DS, Lee OH, Oh SH, LippmanSM, Lee HY. Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF-independent suppressionof Erk1/2 activation and Egr-1-mediated transcriptional events. Blood 2011;118(9): 2622-31.
- Shin DH, Lee HJ, Min HY, Choi SP, Lee MS, Lee JW, Johnson FM, Mehta K, Lippman SM, Glisson BS, Lee HY. Combating Resistance to Anti-IGFR Antibody by Targeting the Integrin β3-Src Pathway. J Natl Cancer Inst 2013;105(20):1558-70.
- Lee JS, Kang JH, Boo HJ, Hwang SJ, Hong S, Lee SC, Park YJ, Chung TM, Yoon H, Lee SM, Kim BJ, Chung JK, Chung Y, William WN, Shin YK, Lee HJ, Oh SH, Lee HY. STAT3-mediated IGF-2 secretion in the tumor microenvironment elicits innate resistance to anti-IGF-1R antibody. Nat Commun 2015;6:8499.
- Lee SC, Min HY, Choi H, Bae SY, Park KH, Hyun SY, Lee HJ, Moon J, Park SH, Kim JY, An H, Park SJ, Seo JH, Lee S, Kim YM, Park HJ, Lee SK, Lee J, Lee J, Kim KW, Suh YG, Lee HY. Deguelin analogue SH-1242 inhibits Hsp90 activity and exerts potent anticancer efficacy with limited neurotoxicity. Cancer Res 2016;76(3):686-99.
- Boo HJ, Min HY, Jang HJ, Yun HJ, Smith JK, Jin Q, Lee HJ, Liu D, Kweon HS, Behrens C, Lee JJ, Wistuba II, Lee E, Hong WK, Lee HY. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun 2016;7:12961.
- Lee SC, Min HY, Jung HJ, Park KH, Hyun SY, Cho J, Woo JK, Kwon SJ, Lee HJ, Lee HY. Essential role of insulin-like growth factor 2 in resistance to histone deacetylase inhibitors. Oncogene 2016;35(42):5515-26.
- Jang HJ, Boo HJ, Lee HJ, Min HY, Lee HY. Chronic stress faciliates lung tumorigenesis by promoting exocytosis of IGF2 in lung epithelial cells. Cancer Res 2016;76(22):6607-19.
- Min HY, Lee SC, Woo JK, Jung HJ, Park KH, Jeong HM, Hyun SY, Cho J, Lee W, Park JE, Kwon SJ, Lee HY, Ni X, Shin YK, Johnson FM, Duvic M, Lee HY. Essential role of DNA methyltransferase 1-mediated transcription of insulin-like growth factor 2 in resistance to histone deacetylase inhibitors. Clin Cancer Res 2017;23(5):1299-1311.
- Lee HJ, Pham PC, Hyun SY, Baek B, Kim B, Kim Y, Min HY, Lee J, Lee HY. Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity. Mol Cancer 2018;17(1):50.
- Min HY, Jang HJ, Park KH, Hyun SY, Park SJ, Kim JH, Son J, Kang SS, Lee HY. The Natural Compound Gracillin Exerts Potent Antitumor Activity by Targeting Mitochondrial Complex II. Cell Death Dis. 2019;10(110):810.
