Education
Ph.D. Faculty of Pharmacy, Heidelberg Universit y
M.S. College of Pharmacy, Seoul National University
B.S. College of Pharmacy, Seoul National University
Research Field
- Drug-induced liver injury (DILI)
- Development of hepatooxicity screening methods
- Chemical-induced fatty liver: mechanisms and treatment
Representative Publication
- Jung, S.H., Lee, W.S., Park S.H., Lee K.Y., Choi, Y.J., Choi, S.H., Kang, D.M., Kim. S.R., Chang. T.S., Hong, S.S. and Lee, B.H. (2020) Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity. Redox biology, 37, 101751
- Sim, W.C., Lee, W.S., Sim. H.T., Lee, K.Y., Jung, S.H., Choi, Y.J., Kim, H.Y., Kang, K.Y., Lee, J.Y., Choi, Y.J., Kim, S.K., Jun, D.W., Kim W and Lee, B.H. (2020) Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease. Metabolism, 102, 154000
- Sim, W.C., Kim, D.G., Lee, W.S., Sim. H.T., Choi, Y.J. and Lee, B.H. (2019) Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. Cell biology and toxicology, 35(5), 457-470
- Lee K.Y., Lee, W.S., Jung, S.H., Park, J.M., Sim. H.T., Choi, Y.J., Park, Y.J., Chung, Y.S. and Lee, B.H. (2019) Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice. Biochem. Pharmacol. 166, 46-55
- Choi, Y.J., Lee, K.Y., Jung, S.H., Kim, H.S., Shim, G., Kim, M.G., Oh, Y.K., Oh, S.H. Jun, D.W. and Lee, B.H. (2017) Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice. Toxicol. Appl. Pharmacol. 316, 74-82
- Sim, W.C., Kim, D.G., Lee, K.J., Choi, Y.J., Choi, Y.J., Shin, K.J., Jun, D.W., Park, S.J., Park, H.J., Kim, J., Oh, W.K., Lee, B.H. (2015) Cinnamamides, novel liver X receptor antagonists inhibit ligand-induced lipogenesis and fatty liver. J. Pharmacol. Exp. Ther. 355(12) 362-369
- Choi, Y.J., Lee, C.H., Lee, K.Y., Jung, S.H. and Lee, B.H. (2015) Increased hepatic fatty acid uptake and esterification contribute to the tetracycline-induced steatosis in mice. Toxicol Sci 145(2) 273-282
- Choi, Y.J., Yoon, Y., Lee, K.Y., Kang, Y.P., Lim, D.K., Kwon, S.W., Kang, K.W., Lee, S.M., and Lee, B.H. (2015) Orotic acid induces insulin resistance and hypertension associated with the impairment of endothelial nitric oxide synthesis. Toxicol Sci 144(2) 307-317
- Sim, W.C., Yin, H.Q., Choi, H.S., Choi, Y.J., Kwak, H.C., Kim, S.K. and Lee, B.H. (2015) L-Serine Supplementation attenuates alcoholic fatty liver by enhancing homocysteine metabolism in mice and rats. J. Nutr. 145(2) 260-267
- Choi, Y.J., Yoon, Y.J., Lee, K.Y., Hien, T.T., Kang, K.W., Kim, K.C., Lee, J., Lee, M.Y., Lee, S.M., Kang, D.H., Lee, B.H. (2014) Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. FASEB J. 28(7), 3197-3204
- Lee, K.Y., Oh, S., Choi, Y.J., Oh, S.H. Yang, Y.S., Yang, M.J., Lee, K. and Lee, B.H. (2013) Activation of autophagy rescues amiodarone-induced apoptosis of lung epithelial cells and pulmonary toxicity in rats. Toxicol. Sci. 136(1) 193-204
- Jung, E.J., Kwon, S.W., Jung, B.H., Oh, S.H. and Lee, B.H. (2011) Role of adenosine monophosphate-activated protein kinase-sterol regulatory element-binding protein-1 pathway in the development of orotic acid-induced fatty liver. J Lipid Res., 52(9) 1617-1625
- Yin, H.Q., Kim, Y.C., Chung, Y.S. Kim, Y.C. and Lee, B.H. (2009) Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes. Toxicol. Appl. Pharmacol. 236(1), pp. 124-130
- Yin, H.Q., Kim, M., Kim, J.H., Kong, G., Kang, K.S., Kim, H.L., Yoon, B.I., Lee, M.O. and Lee, B.H. (2009) Analysis of hepatic gene expression during fatty liver change due to chronic ethanol administration in mice. Toxicol. Appl. Phamacol. 235(3), pp. 312-320 (2009)
- Li, GY, Lee, HY, Shin, HS, Kim, HY, Lim, CH and Lee, B.H. (2007) Identification of gene markers for evaluation of exposure to formaldehyde in human. Environ. Health Perspect. 115(10) 1460-1466
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