Research Field
- Identification of pharmacological target(s) for the reversal of chemotherapy resistance
- Identification of pharmacological target(s) for the treatment of chronic vascular diseases and screening of drug candidates
Representative Publication
- Phuong NTT, Kim SK, Lim SC, Kim HS, Kim TH, Lee KY, Ahn SG, Yoon JH, Kang KW. Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells. Breast Cancer Res Treat. 2011, in press.
- Oh WK, Cho KB, Hien TT, Kim TH, Kim HS, Dao TT, Han HK, Kwon SM, Ahn SG, Yoon JH, Kim TH, Kim YG, Kang KW. Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1. Mol Pharmacol. 2010, 78(5):855-64.
- Kim SE, Lee MY, Lim SC, Hien TT, Kim JW, Ahn SG, Yoon JH, Kim SK, Choi HS, Kang KW. Role of Pin1 in the neointima formation: Down-regulation of Nrf2-dependent heme oxygenase-1 expression by Pin1. Free Radic Biol Med. 2010 48(12):1644-53.
- Hien TT, Kim ND, Pokharel YR, Oh SJ, Lee MY, Kang KW. Ginsenoside Rg3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: Essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase. Toxicol Appl Pharmacol. 2010, 246(3):171-183.
- Kim JW, Lim SC, Lee MY, Lee JW, Oh WK, Kim SK, Kang KW. Inhibition of neointimal formation by trans-resveratrol : Role of PI3-kinase-dependent Nrf2 activation in heme oxygenase-1 induction. Mol Nutr Food Res. 2010 54(10):1497-505.
- Kang KW, Chun MK, Kim O, Subedi RK, Ahn SG, Yoon JH, Choi HK. Doxorubicin-loaded solid lipid nanoparticles to overcome multidrug resistance in cancer therapy. Nanomedicine. 2010 6(2):210-3.
- Cho KB, Cho MK, Lee WY, Kang KW. Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells. Cancer Lett. 2010 293(2):230-9.
- Pokharel YR, Kim ND, Han HK, Oh WK, Kang KW. Increased ubiquitination of multidrug resistance 1 by ginsenoside Rd. Nutr Cancer. 2010 62(2):252-9
- Jeong HG, Pokharel YR, Lim SC, Hwang YP, Han EH, Yoon JH, Ahn SG, Lee KY, Kang KW. Novel Role of Pin1 Induction in Type II Collagen-Mediated Rheumatoid Arthritis. J Immunol. 2009 183(10):6689-97.
- Kim MR, Choi HS, Yang JW, Park BC, Kim JA, Kang KW. Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression. Mol Cancer Ther. 2009 8(8):2163-71.
Research Field
