Education
1981. 3 ~ 1985. 2 : College of Pharmacy, Seoul National University (BS)
1985. 3 ~ 1987. 2 : College of Pharmacy, Seoul National University (MS)
1993. 9 ~ 1997. 8 : Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago (Ph.D)
Career
2010. 3 ~ present : Seoul National University (Associate Professor)
2009. 3 ~ 2010. 2 : Ewha Womans University (Professor)
2004. 3 ~ 2009. 2 : Ewha Womans University (Associate Professor)
2006. 1 ~ 2007. 2 : Stanford University (Stanford University)
2000. 3 ~ 2004. 2 : Ewha Womans University (Assistant Professor)
Research Field
Identification of anti-cancer agents from bioactive natural products or related synthetic compounds, and study of mechanism of action of potential compounds
Representative Publication
- Min HY, Song SH, Lee B, Kim S, Lee SK (2010) Inhibition of lipopolysaccharide-induced nitric oxide production by antofine and its analogues in RAW 264.7 macrophage cells. Chem Biodivers. 7(2):409-14.
- Hong JY, Nam JW, Seo EK, Lee SK (2010) Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa. Chem Pharm Bull (Tokyo). 58(2):234-7.
- Kim SJ, Min HY, Lee EJ, Kim YS, Bae K, Kang SS, Lee SK (2010) Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells. Phytother Res. 24(2):193-7.
- Song SH, Min HY, Han AR, Nam JW, Seo EK, Park SW, Lee SH, Lee SK (2009) Suppression of inducible nitric oxide synthase by (-)-isoeleutherin from the bulbs of Eleutherine americana through the regulation of NF-kappaB activity. Int Immunopharmacol. 9(3):298-302.
- Park EJ, Min HY, Chung HJ, Hong JY, Kang YJ, Hung TM, Youn UJ, Kim YS, Bae K, Kang SS, Lee SK (2009) Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer Lett. 277(2):133-40.
- Park EJ, Choi SJ, Kim YC, Lee SH, Park SW, Lee SK (2009) Novel small molecule activators of beta-catenin-mediated signaling pathway:structure-activity relationships of indirubins. Bioorg Med Chem Lett. 19(8):2282-4.
- Min HY, Kim MS, Jang DS, Park EJ, Seo EK, Lee SK (2009) Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells. Int Immunopharmacol. 9(7-8):844-9.
- Son SH, Kim MJ, Chung WY, Son JA, Kim YS, Kim YC, Kang SS, Lee SK, Park KK (2009) Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. Cancer Lett. 280(1):86-92.
- Jeong LS, Tosh DK, Choi WJ, Lee SK, Kang YJ, Choi S, Lee JH, Lee H, Lee HW, Kim HO (2009) Discovery of a new template for anticancer agents: 2′-deoxy-2′-fluoro-4′-selenoarabinofuranosyl-cytosine (2′-F-4′-seleno-ara-C). J Med Chem. 10;52(17):5303-6.
- Kang YJ, Park KK, Chung WY, Hwang JK, Lee SK (2009) Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. J Pharmacol Sci. 111(3):276-84.
- Jeong LS, Pal S, Choe SA, Choi WJ, Jacobson KA, Gao Z, Klutz AM, Hou X, Kim HO, Lee HW, Lee SK, Tosh DK, and Moon HR (2009) Structure-activity relationships of truncated D- and l-4′-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. J. Med. Chem., 51: 6609-6613
- Lee CK, Park K, Hwang J, Lee SK, Chung W (2009) Extract of Prunus persica flesh (PPFE) improves chemotherapeutic efficacy and protects against nephrotoxicity in cisplatin-treated mice. Phytotherapy Res., 23: 999-1005.
- Min HY, Kim MS, Jang DS, Park EJ, Seo EK, Lee SK (2009) Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) Int Immuno pharmacol. 9: 844-849.
- Son SH, Kim MJ, Chung WY, Son JA, Kim YS, Kim YC, Kang SS, Lee SK, Park KK (2009) Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase Cancer Lett., 280: 86-92.
- Pal S, Choi WJ, Choe SA, Heller CL, Gao ZG, Chinn M, Jacobson KA, Hou X, Lee SK, Kim HO, Jeong LS (2009) Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. Bioorg. Med. Chem. 17: 3733-3738.
- Kim SJ, Min HY, Lee EJ, Kim YS, Bae KH, Kang SS, Lee SK (2009) Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells. Phytotherapy Res., 22: 223-227.
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