Education
Ph.D. University of Wisconsin-Madison
Career
2009 – present : Associate professor, College of Pharmacy, Seoul National University
2009 – 2013 : Assistant professor, College of Pharmacy, Seoul National University
2006 – 2009 : Research Associate, Dept. of Molecular Biology, The Scripps Research Institute (TSRI)
2001 – 2001 : Researcher (with M.S. degree), Dept. of Chemistry, Seoul National University
Research Field
- Structure-function relationships of biomedically important proteins
- Structural biology on tumor microenvironment-modulating proteins
- Structural biology on the N-degron pathway in protein degradation
- Structural biology on aminoacyl-tRNA synthetases and the multi-tRNA synthetase complex
- Variable lymphocyte receptor (VLR); structure, engineering, and application
Representative Publication
- “Membrane association, mechanism of action, and structure of Arabidopsis EMBRYONIC FACTOR 1 (FAC1)” Han, B.W., Bingman, C.A., Mahnke, D.K., Bannen, R.M., Sabina, R.L. & Phillips, G.N., Jr. (2006) Journal of Biological Chemistry, 281(21):14939-47, 2006. 05. 26.
- “Antigen recognition by variable lymphocyte receptors” Han, B.W., Herrin, B.R., Cooper, M.D., and Wilson, I.A. (2008) Science, 321(5897):1834-7, 2008. 09. 26.
- “Structural and functional characterizations of HP0377, a thioredoxin-fold protein from Helicobacter pylori” Yoon, J.Y., Kim, J.E., An, D.R., Lee, S.J., Kim, H.S., Im, H.N., Yoon, H.-J., Kim, J.Y., Kim, S.-J., Han, B.W.,† Suh, S.W.† (2013) Acta Crystallographica Section D Biological Crystallography, 69(Pt5):735-46, 2013. 05. († co-corresponding authors)
- “Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction” Kim, D.G., Lee, J.Y., Kwon, N.H., Fang, P., Zhang, Q., Wang, J., Young, N.L., Guo, M., Cho, H.Y., Mushtaq, A.U., Jeon, Y.H., Choi, J.W., Han, J.M., Kang, H.W., Joo, J.E., Hur, Y., Kang, W., Yang, H., Nam, D.H., Lee, M.S., Lee, J.W., Kim, E.S., Moon, A., Kim, K., Kim, D., Kang, E.J., Moon, Y., Rhee, K.H., Han, B.W., Yang, J.S., Han, G., Yang, W.S., Lee, C., Wang, M.W., and Kim, S. (2014) Nature Chemical Biology, 10(1):29-34, 2014. 01.
- “Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation against oxidative stresses” Lee, J.Y., Kim, D.G., Kim, B.G., Yang, W.S., Hong, J., Kang, T., Oh, Y.S., Kim, K.R., Han, B.W., Hwang, B., Kang, B., Kang, M.S., Kim, M.H., Kwon, N.H., and Kim, S. (2014) Journal of Cell Science, 127(Pt 19):4234-45, 2014. 10. 01.
- “PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine”Lee, J.H., Park, K.M., Han, D.J., Bang, N.Y., Kim, D.H., Na, H., Lim, S., Kim, T.B., Kim, D.G., Kim, H.J., Chung, Y., Sung, S.H., Surh, Y.J., Kim, S., and Han, B.W. (2015) PLoS One, 10(11):e0142624, 2015. 11.
- “Structure and Stability of the Dimeric Triosephosphate Isomerase from the Thermophilic Archaeon Thermoplasma acidophilum”Park, S.H., Kim, H.S., Park, M.S., Moon, S., Song, M.K., Park, H.S., Hahn, H., Kim, S.J., Bae, E., Kim, H.J., and Han, B.W. (2015) PLoS One, 10(12):e0145331, 2015.12.28.
- “Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection”Ahn, Y.H., Park, S., Choi, J.J., Park, B.K., Rhee, K.H., Kang, E., Ahn, S., Lee, C.H., Lee, J.S., Inn, K.S., Cho, M.L., Park, S.H., Park, K., Park, H.J., Lee, J.H., Park, J.W., Kwon, N.H., Shim, H., Han, B.W., Kim, P., Lee, J.Y., Jeon, Y., Huh, J.W., Jin, M., and Kim, S. (2016) Nature Microbiology, 2016 Oct 17;2:16191. doi: 10.1038/nmicrobiol.2016.191
- “Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ”Jang JY, Bae H, Lee YJ, Choi YI, Kim HJ, Park SB, Suh SW, Kim SW†, and Han, B.W.† (2018) Scientific Reports, 2018 Jan 8;8(1):31. doi: 10.1038/s41598-017-18274-1. PMID: 29311579, († co-corresponding authors)
- “Molecular organization of the type II-A CRISPR adaptation module and its interaction with Cas9 via Csn2″Ka D, Jang DM, Han, B.W., and Bae E. Nucleic Acids Research, 2018 Aug 8. doi: 10.1093/nar/gky702. [Epub ahead of print] PMID: 30102386
- “Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity.”Park JS, Park MC, Lee KY, Goughnour PC, Jeong SJ, Kim HS, Kim HJ, Lee BJ, Kim S, and Han, B.W. International Journal of Biological Macromolecules, 2018 Dec;120(Pt A):835-845. doi: 10.1016/j.ijbiomac.2018.08.171. Epub 2018 Aug 30. PMID: 30171954
- “Synergistic AML cell death induction by marine cytotoxin (+)-1(R), 6(S), 1′(R), 6′(S), 11(R), 17(S)-fistularin-3 and Bcl-2 inhibitor Venetoclax.” Cristina Florean, Kyung Rok Kim, Michael Schnekenburger, Hyun-Jung Kim, Céline Moriou, Cécile Debitus, Mario Dicato, Ali Al-Mourabit, Han, B.W.†, and Marc Diederich† Marine Drugs, 2018, 16, 518; doi:10.3390/md16120518 (†co-corresponding authors)
- “Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation” Jun Young Jang*, Hyun Soo Kim*, Hyun-Jung Kim, Se Won Suh, Seung Bum Park†, and Han, B.W.† Scientific Reports, 2019 Aug 1;9(1):11168. doi: 10.1038/s41598-019-47672-w. PMID: 31371757 (* equally contributed, † co-corresponding authors)
- “DRS–AIMP2–EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex” Hyunggu Hahn*, Sang Ho Park*, Hyun-Jung Kim, Sunghoon Kim, and Han, B.W. IUCr Journal (2019) 6:958-967, https://doi.org/10.1107/S2052252519010790 (* equally contributed)
- “Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.” Sliepen K*, Han, B.W.†, Bontjer I*, Mooij P, Garces F, Behrens AJ, Rantalainen K, Kumar S, Sarkar A, Brouwer PJM, Hua Y, Tolazzi M, Schermer E, Torres JL, Ozorowski G, van der Woude P, de la Peña AT, van Breemen MJ, Camacho-Sánchez JM, Burger JA, Medina-Ramírez M, González N, Alcami J, LaBranche C, Scarlatti G, van Gils MJ, Crispin M, Montefiori DC, Ward AB, Koopman G, Moore JP, Shattock RJ, Bogers WM, Wilson IA†, and Sanders RW† Nature Communications, 2019 May 29;10(1):2355. doi: 10.1038/s41467-019-10262-5. PMID: 31142746 (* equally contributed, † co-corresponding authors)
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