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서울대학교 서울대학교 약학대학

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교수진

이승희 교수

이승희 사이트로 이동
전공약물학 (분자세포생물학)
주소143-306
연락처880-2478 / 880-2518
이메일leeseung@snu.ac.kr
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학력

2001년 : 전남대학교 약학대학 / 학사

2006년 : Baylor College of Medicine / 박사

주요경력

2006년 5월 – 2010년 6월 : Baylor College of Medicine, Post Doctoral Associate

2010년 7월 – 2011년 3월 : Oregon Health & Science University, Post Doctoral Associate

2011년 4월 – 2012년 2월 : Oregon Health & Science University, Research Assistant Professor

2012년 3월 – 2016년 2월 : 서울대학교 약학대학 조교수

2016년 3월 – 2021년 8월 : 현재: 서울대학교 약학대학 부교수

2021년 9월 – 현재 : 서울대학교 약학대학 교수

주요관심 연구분야
  • 배아 중추신경발달 유전자조절 네트워크
  • 줄기세포 후성유전조절
  • 대사 및 암화 유전자조절 네트워크
대표논문자료
  1. Huisman C, Kim YA, Jeon S, Shin B, Choi J, Lim SJ, Youn SM, Park Y, Medha K C, Kim S, Lee SK, Lee S*, Lee JW*. The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus. Nature Communications, 2021 Jan 11;12(1):256.
  2. Han YH, Kim HJ, Choi H, Lee S, Lee MO. RORα autoregulates its transcription via MLL4-associated enhancer remodeling in the liver. Life Sci. 2020 Sep 1;256:118007.
  3. Cho H, Lee JY, Choi SY, Lim C, Park MK, An H, Lee JO, Noh M, Lee S*, Kim S*. Identification of a New Chemotype of Anti-Obesity Compounds by Ensemble Screening. ACS Omega. 2020 Feb 20;5(8):4338-4346.
  4. Kim J, Lee B, Kim DH, Yeon JG, Lee J, Park Y, Lee Y, Lee SK, Lee S*, Lee JW*. UBE3A suppresses overnutrition-induced expression of the steatosis target genes of MLL4 by degrading MLL4. Hepatology. 2019 Mar;69(3):1122-1134
  5. Kim J, Choi TI, Park S, Kim MH, Kim CH, Lee S*. Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains. Development. 2018 Sep 3;145(17). (recommended by Faculty of 1000 Biology)
  6. Lee B, Kim J, An T, Kim S, Patel EM., Raber J, Lee SK, Lee S* & Lee JW*. Dlx1/2 and Otp coordinate the production of hypothalamic GHRH-and AgRP-neurons. Nature Communications, 2018 May 23; 9:2026
  7. Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S*, Lee JW*. Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2. Cell Rep. 2016 Nov 1;17(6):1671-1682.
  8. Lee B, Lee S*, Lee SK, Lee JW*. The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons. Development. 2016 Oct 15;143(20):3763-3773
  9. Clovis Y, Seo SY, Kwon JS, Rhee JC, Yeo S, Lee JW, Lee S*, and Lee SK*. Chx10 consolidates V2a interneuron identity through two distinct gene repression modes. Cell Reports, 2016 Aug 9;16(6):1642-52
  10. Nam H, Lee S*. Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons. Development, 2016 Jul 1;143(13):2334-43 (recommended by Faculty of 1000 Biology)
  11. Seo SY, Lee B, and Lee S*. Critical roles of the LIM domains of Lhx3 in recruiting coactivators to the motor neuron-specifying Isl1-Lhx3 complex. Mol Cell Biol, 2015 Oct 15;35(20):3579-89. (highlighted in Spotlight as a hot paper)
  12. Thiebes KP, Nam H, Cambronne XA, Shen R, Glasgow SM, Cho H, Kwon J, Goodman RH, Lee JW, Lee S*, and Lee SK*. miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3. Nature Communications, 2015 Jul 27;6:7718.
  13. Kim DH, Rhee JC, Yeo S, Shen R, Lee SK, Lee JW, and Lee S*. Crucial roles of MLL3 and MLL4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis. Hepatology 61, 1012-1023, 2015
  14. Cho HH, Cargnin F, Kim Y, Lee B, Kwon RJ, Nam H, Shen R, Barnes AP, Lee JW,
    Lee S*, and Lee SK*. Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. Plos Genetics 10, e1004280, 2014.
  15. Kim SG, Lee B, Kim DH, Kim J, Lee S*, Lee SK, and Lee JW*. Control of energy balance by a hypothalamic gene circuitry involving two nuclear receptors, NOR1 and GR. Mol Cell Biol 33, 3826-34, 2013
  16. Lee S*, Shen R, Cho HH, Kwon RJ, Seo SY, Lee JW, and Lee SK*. Stat3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex. Proc Natl Acad Sci USA 110, 11445-50, 2013
  17. Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK. Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs. Proc Natl Acad Sci USA 109(9), 3383-8, 2012
  18. Lee S, Lee JW, and Lee SK. UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Developmental Cell 22, 1-13, 2012
  19. Lee S and Lee.SK. Crucial roles of histone-modifying enzymes in mediating neural cell-type specification. Curr Opin Neurobiol 20:29-36, 2010
  20. Lee S, Lee B, Lee JW, and Lee SK. Retinoid signaling and Ngn2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron 62, 641-54, 2009
  21. Joshi K, Lee S, Lee B, Lee JW, and Lee SK. LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron 61, 839-51, 2009
  22. Lee S, Roeder RG, and Lee JW. Roles of histone H3-lysine 4 methyltransferase complexes in NR-mediated gene transcription. Prog Mol Biol Transl Sci 87C:343-382, 2009
  23. Lee JK, Kim DH, Lee S, Yang Q, Lee DK, Lee SK, Roeder RG, and Lee JW. A tumor suppressive coactivator complex of p53 containing histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci USA 106, 8513-8, 2009
  24. Lee S, Lee B, Joshi K, Pfaff S, Lee JW, and Lee SK. A regulatory network to segregate spinal neuronal subtypes. Developmental Cell 14, 877-89, 2008
  25. Lee S, Lee J, Lee SK, and Lee JW. Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferase MLL3 and MLL4 to the liver X receptors. Mol Endocrinol 22, 1312-9, 2008
  26. Lee S, Lee DK, Dou Y, Lee J, Lee B, Kwak E, Kong YY, Lee SK, Roeder RG, Lee JW. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci USA 103,15392-7,2006
  27. Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW , Verdine GL, Allis CD, Roeder RG. Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol 13, 713-9, 2006
  28. Lee S, Lee DK, Choi E, Lee JW. Identification of a functional vitamin D response element in the murine Insig-2 promoter and its potential role in the differentiation of 3T3-L1 preadipocytes. Mol Endocrinol 19,399-408, 2005
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