학술행사/세미나 안내 및 신청
Understanding the Dynamics of Endoplasmic Reticulum Membrane Domains
연사
장원열 교수
세미나개최일
2025. 02. 18. (화) 오전 11시 (20동 102호)
작성자
정연석
작성일
2025-02-12
조회
74
Understanding the Dynamics of Endoplasmic Reticulum Membrane Domains
Wonyul Jang1
1 School of Biological Sciences, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea
Eukaryotic cells contain a variety of intracellular lipid membrane-bound compartments called organelles that mediate the important biochemical functions necessary for life. Unlike our classic textbook image of organelles usually depicted as static and isolated, emerging pictures show organelles undergo dynamic fusion, and fission, and actively communicate with each other by establishing close apposition between the membranes of two organelles, the so-called membrane contact sites. Rewiring such organelle dynamics is essential for cells to appropriately adapt to altering environments such as nutrient deprivation. In contrast to other organelles that have multiple copies in cells, each cell contains only one ER. This ER extends throughout the cell and occupies a large fraction of the cytoplasmic volume via its elaborate, giant membrane architecture consisting of different morphological domains, namely tubule, sheets, and nuclear envelope. However, the underlying mechanism of ER morphological dynamics and the relationship between its form and function still remain elusive. In this talk, I will present how cells reshape ER during nutrient starvation and rewire their metabolic states by communicating with neighboring organelles.
Keywords: Endoplasmic reticulum, membrane contact site, lipid metabolism
Wonyul Jang1
1 School of Biological Sciences, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826, Republic of Korea
Eukaryotic cells contain a variety of intracellular lipid membrane-bound compartments called organelles that mediate the important biochemical functions necessary for life. Unlike our classic textbook image of organelles usually depicted as static and isolated, emerging pictures show organelles undergo dynamic fusion, and fission, and actively communicate with each other by establishing close apposition between the membranes of two organelles, the so-called membrane contact sites. Rewiring such organelle dynamics is essential for cells to appropriately adapt to altering environments such as nutrient deprivation. In contrast to other organelles that have multiple copies in cells, each cell contains only one ER. This ER extends throughout the cell and occupies a large fraction of the cytoplasmic volume via its elaborate, giant membrane architecture consisting of different morphological domains, namely tubule, sheets, and nuclear envelope. However, the underlying mechanism of ER morphological dynamics and the relationship between its form and function still remain elusive. In this talk, I will present how cells reshape ER during nutrient starvation and rewire their metabolic states by communicating with neighboring organelles.
Keywords: Endoplasmic reticulum, membrane contact site, lipid metabolism
