SEOUL NATIONAL UNIVERSITY
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Han, Byung Woo사진
  • 성명 Han, Byung Woo
  • 직위 Professor
  • 학과 Dept. of Pharmacy
  • 전공 Biochemistry
  • 사무실 141-405
  • 홈페이지 http://bwhan.snu.ac.kr/
  • 이메일 bwhan@snu.ac.kr
  • 연락처 02-880-7898 (Office) / 02-880-7899 (Lab)

Education

Ph.D. University of Wisconsin-Madison

Career

2009 - present : Associate professor, College of Pharmacy, Seoul National University

2009 - 2013 : Assistant professor, College of Pharmacy, Seoul National University

2006 - 2009 : Research Associate, Dept. of Molecular Biology, The Scripps Research Institute (TSRI)

2001 - 2001 : Researcher (with M.S. degree), Dept. of Chemistry, Seoul National University

Research Field

1. Structure-function relationships of biomedically important proteins
2. Structural biology on tumor microenvironment-modulating proteins
3. Structural biology on the N-degron pathway in protein degradation
4. Structural biology on aminoacyl-tRNA synthetases and the multi-tRNA synthetase complex
5. Variable lymphocyte receptor (VLR); structure, engineering, and application

Representative Publication

15. "Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence." Sliepen K*, Han, B.W.†, Bontjer I*, Mooij P, Garces F, Behrens AJ, Rantalainen K, Kumar S, Sarkar A, Brouwer PJM, Hua Y, Tolazzi M, Schermer E, Torres JL, Ozorowski G, van der Woude P, de la Peña AT, van Breemen MJ, Camacho-Sánchez JM, Burger JA, Medina-Ramírez M, González N, Alcami J, LaBranche C, Scarlatti G, van Gils MJ, Crispin M, Montefiori DC, Ward AB, Koopman G, Moore JP, Shattock RJ, Bogers WM, Wilson IA†, and Sanders RW† Nature Communications, 2019 May 29;10(1):2355. doi: 10.1038/s41467-019-10262-5. PMID: 31142746 (* equally contributed, † co-corresponding authors)

14. "DRS–AIMP2–EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex" Hyunggu Hahn*, Sang Ho Park*, Hyun-Jung Kim, Sunghoon Kim, and Han, B.W. IUCr Journal (2019) 6:958-967, https://doi.org/10.1107/S2052252519010790 (* equally contributed)

13. "Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation" Jun Young Jang*, Hyun Soo Kim*, Hyun-Jung Kim, Se Won Suh, Seung Bum Park†, and Han, B.W.† Scientific Reports, 2019 Aug 1;9(1):11168. doi: 10.1038/s41598-019-47672-w. PMID: 31371757 (* equally contributed, † co-corresponding authors)

12. "Synergistic AML cell death induction by marine cytotoxin (+)-1(R), 6(S), 1′(R), 6′(S), 11(R), 17(S)-fistularin-3 and Bcl-2 inhibitor Venetoclax." Cristina Florean, Kyung Rok Kim, Michael Schnekenburger, Hyun-Jung Kim, Céline Moriou, Cécile Debitus, Mario Dicato, Ali Al-Mourabit, Han, B.W.†, and Marc Diederich† Marine Drugs, 2018, 16, 518; doi:10.3390/md16120518 (†co-corresponding authors)

11. "Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity."Park JS, Park MC, Lee KY, Goughnour PC, Jeong SJ, Kim HS, Kim HJ, Lee BJ, Kim S, and Han, B.W. International Journal of Biological Macromolecules, 2018 Dec;120(Pt A):835-845. doi: 10.1016/j.ijbiomac.2018.08.171. Epub 2018 Aug 30. PMID: 30171954

10. "Molecular organization of the type II-A CRISPR adaptation module and its interaction with Cas9 via Csn2"Ka D, Jang DM, Han, B.W., and Bae E. Nucleic Acids Research, 2018 Aug 8. doi: 10.1093/nar/gky702. [Epub ahead of print] PMID: 30102386

9. "Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ"Jang JY, Bae H, Lee YJ, Choi YI, Kim HJ, Park SB, Suh SW, Kim SW†, and Han, B.W.† (2018) Scientific Reports, 2018 Jan 8;8(1):31. doi: 10.1038/s41598-017-18274-1. PMID: 29311579, († co-corresponding authors)

8. "Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection"Ahn, Y.H., Park, S., Choi, J.J., Park, B.K., Rhee, K.H., Kang, E., Ahn, S., Lee, C.H., Lee, J.S., Inn, K.S., Cho, M.L., Park, S.H., Park, K., Park, H.J., Lee, J.H., Park, J.W., Kwon, N.H., Shim, H., Han, B.W., Kim, P., Lee, J.Y., Jeon, Y., Huh, J.W., Jin, M., and Kim, S. (2016) Nature Microbiology, 2016 Oct 17;2:16191. doi: 10.1038/nmicrobiol.2016.191

7. "Structure and Stability of the Dimeric Triosephosphate Isomerase from the Thermophilic Archaeon Thermoplasma acidophilum"Park, S.H., Kim, H.S., Park, M.S., Moon, S., Song, M.K., Park, H.S., Hahn, H., Kim, S.J., Bae, E., Kim, H.J., and Han, B.W. (2015) PLoS One, 10(12):e0145331, 2015.12.28.

6. "PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine"Lee, J.H., Park, K.M., Han, D.J., Bang, N.Y., Kim, D.H., Na, H., Lim, S., Kim, T.B., Kim, D.G., Kim, H.J., Chung, Y., Sung, S.H., Surh, Y.J., Kim, S., and Han, B.W. (2015) PLoS One, 10(11):e0142624, 2015. 11.

5. "Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation against oxidative stresses" Lee, J.Y., Kim, D.G., Kim, B.G., Yang, W.S., Hong, J., Kang, T., Oh, Y.S., Kim, K.R., Han, B.W., Hwang, B., Kang, B., Kang, M.S., Kim, M.H., Kwon, N.H., and Kim, S. (2014) Journal of Cell Science, 127(Pt 19):4234-45, 2014. 10. 01.

4. "Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction" Kim, D.G., Lee, J.Y., Kwon, N.H., Fang, P., Zhang, Q., Wang, J., Young, N.L., Guo, M., Cho, H.Y., Mushtaq, A.U., Jeon, Y.H., Choi, J.W., Han, J.M., Kang, H.W., Joo, J.E., Hur, Y., Kang, W., Yang, H., Nam, D.H., Lee, M.S., Lee, J.W., Kim, E.S., Moon, A., Kim, K., Kim, D., Kang, E.J., Moon, Y., Rhee, K.H., Han, B.W., Yang, J.S., Han, G., Yang, W.S., Lee, C., Wang, M.W., and Kim, S. (2014) Nature Chemical Biology, 10(1):29-34, 2014. 01.

3. "Structural and functional characterizations of HP0377, a thioredoxin-fold protein from Helicobacter pylori" Yoon, J.Y., Kim, J.E., An, D.R., Lee, S.J., Kim, H.S., Im, H.N., Yoon, H.-J., Kim, J.Y., Kim, S.-J., Han, B.W.,† Suh, S.W.† (2013) Acta Crystallographica Section D Biological Crystallography, 69(Pt5):735-46, 2013. 05. († co-corresponding authors)

2. “Antigen recognition by variable lymphocyte receptors” Han, B.W., Herrin, B.R., Cooper, M.D., and Wilson, I.A. (2008) Science, 321(5897):1834-7, 2008. 09. 26.

1. “Membrane association, mechanism of action, and structure of Arabidopsis EMBRYONIC FACTOR 1 (FAC1)” Han, B.W., Bingman, C.A., Mahnke, D.K., Bannen, R.M., Sabina, R.L. & Phillips, G.N., Jr. (2006) Journal of Biological Chemistry, 281(21):14939-47, 2006. 05. 26.

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