SEOUL NATIONAL UNIVERSITY
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Ja Hyun Koo사진
  • 성명 Ja Hyun Koo
  • 직위 Assistant professor(Ph.D. Seoul National University)
  • 학과 Pharmacy
  • 전공 Pharmacology
  • 사무실 20-325
  • 홈페이지 https://www.koolab.net
  • 이메일 jhkoo@snu.ac.kr
  • 연락처 880-7839/880-7854

Education

B.S., Seoul National University (2010)
Ph.D. Seoul National University (2017)

Academic career

2017-2019 Postdoctoral Fellow, University of California at San Diego
2019-2021 Asst. Professor, The Catholic Universtiy of Korea (2019-2021)
2021-present Asst. Professor, Seoul National University

Representative Publication

1. “Ablation of USP21 in skeletal muscle promotes oxidative fiber phenotype, inhibiting obesity and type 2 diabetes” Kim A, Koo JH, J Xing, Park SY, Kim W, Park S, Choi CS, Rhee EP, Kim SG* Journal of Cachexia, Sarcopenia and Muscle, 2021; in press.

2. “Signaling nodes associated with endoplasmic reticulum stress during NAFLD progression” Koo JH*, Han CY* (*co-correspondence) Biomolecules, 2021; 11(2):242.

3. “Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth” Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL Genes & Development, 2020; 34:72-86.

4. “Liver X receptor α-induced cannabinoid receptor 2 inhibits ubiquitin-specific peptidase 4 through miR-27b, protecting hepatocytes from TGF-β” Wu HM, Kim TH, Kim A, Koo JH, Joo MS, Kim SG. Hepatology Communications, 2019; 3(10):1373-87.

5. “ITIH1 overproduction by loss of Gα13 in liver exacerbates systemic insulin resistance” Kim TH, Koo JH, Heo MJ, Han CY, Kim YI, Park SY, Cho IJ, Lee CH, Choi CS, Lee JW, Kim W, Cho JY, Kim SG. Science Translational Medicine, 2019; 11(513):eaan4735.

6. “Nrf2-lncRNA controls cell fate by modulating p53-dependent Nrf2 activation as a miRNA sponge for Plk2 and p21cip1” Joo, MS, Shin SB, Kim EJ, Koo JH, Yim H, Kim SG. FASEB Journal, 2019; 33(7):7953-969.

7. “Cell type-dependent function of LATS1/2 in cancer cell growth” Pan WW, Moroishi T, Koo JH, Guan KL. Oncogene, 2019; 38(14):2595-610.

8. “LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis” Joo MS*, Koo JH*, Kim TH, Kim YS, Kim SG. (*equally contributed) EBioMedicine, 2019; 40:488-503.

9. “Interplay between YAP/TAZ and metabolism” Koo JH, Guan KL. Cell Metabolism, 2018; 28(2):196-206.

10. “Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration” Kim TH*, Yang YM*, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG. (*equally contributed) Journal of Clinical Investigation, 2018; 128(12):5587-602.

11. “Gα12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells”  Kim KM, Han CY, Kim JY, Cho SS, Kim YS, Koo JH, Lee JM, Lim SC, Kang KW, Kim JS, Hwang SJ, Ki SH, Kim SG. Journal of Hepatology, 2018; 68(3):493-504.

12. “Gα12 regulates osteoclastogenesis by modulating NFATc1 expression” Song MK, Park C, Lee YD, Kim H, Kim MK, Kwon JO, Koo JH, Joo MS, Kim SG, Kim HH. Journal of Cellular and Molecular Medicine, 2018; 22(2):849-60.

13. “Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism” Koo JH, Kim TH, Park SY, Joo MS, Han CY, Choi CS, Kim SG. Journal of Clinical Investigation, 2017; 127(10):3845-60. > Highlighted on the “JCI This Month Editor’s Picks”.

14. “Oligopeptide competition assay for phosphorylation site determination” Joo MS, Koo JH, Shin SB, Yim H, Kim SG. Journal of Visualized Experiments, 2017; 123:e55708.

15. “Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt” Han CY, Koo JH, Kim SH, Gardenghi S, Rivella S, Strnad P, Hwang SJ, Kim SG. Nature Communications, 2016; 22(7):13817.

16. “Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function” Han CY*, Kim TH*, Koo JH, Kim SG. (*equally contributed) Archives of Pharmacal Research, 2016; 39(8):1062-74.

17. “PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury” Han CY, Lim SW, Koo JH, Kim W, Kim SG. Gut, 2016; 65(8):1377-88.

18. “AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine 550” Joo MS*, Kim WD*, Lee KY, Kim JH, Koo JH, Kim SG. (*equally contributed) Molecular and Cellular Biology, 2016; 36(14):1931-42.

19. “Endoplasmic reticulum stress in hepatic stellate cells promotes liver fibrosis via PERK-mediated degradation of HNRNPA1 and upregulation of SMAD2” Koo JH, Lee HJ, Kim W, Kim SG. Gastroenterology, 2016; 150(1):181-93.

20. “Phytochemical regulation of Fyn and AMPK signaling circuitry” Lee CG*, Koo JH*, Kim SG. (*equally contributed) Archives of Pharmacal Research, 2015; 38(12):2093-105.

21. “Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction” Yang YM, Lee CG, Koo JH, Kim TH, Lee JM, An J, Kim KM, Kim SG. Oncotarget, 2015; 6(22):19055-69.

22. “microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression” Heo MJ, Kim YM, Koo JH, Yang YM, An J, Lee SK, Lee SJ, Kim KM, Park JW, Kim SG. Oncotarget, 2014; 5(9):2792-806.

23. “Gα12 gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR-135b and miR-194 dysregulation” Jung HS*, Seo YR*, Yang YM, Koo JH, An J, Lee SJ, Kim KM, Kim SG. (*equally contributed) Cellular Signalling, 2014; 26(7):1456-65.

24. “miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury” Joo MS, Lee CG, Koo JH, Kim SG. Cell Death & Disease, 2013; 4:e899.

25. “Fyn Inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury” Koo JH, Lee WH, Lee CG, Kim SG. Molecular Pharmacology, 2012; 82:27-36.

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