SEOUL NATIONAL UNIVERSITY
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이상국사진

연구실소개

학  력

1981. 3 ~ 1985. 2 : College of Pharmacy, Seoul National University (BS)
1985. 3 ~ 1987. 2 : College of Pharmacy, Seoul National University (MS)
1993. 9 ~ 1997. 8 : Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago (Ph.D)

주요경력

2010. 3 ~ present : Seoul National University (Associate Professor)
2009. 3 ~ 2010. 2 : Ewha Womans University (Professor)
2004. 3 ~ 2009. 2 : Ewha Womans University (Associate Professor)
2006. 1 ~ 2007. 2 : Stanford University (Stanford University)
2000. 3 ~ 2004. 2 : Ewha Womans University (Assistant Professor)

주요관심연구분야

Identification of anti-cancer agents from bioactive natural products or related synthetic compounds, and study of mechanism of action of potential compounds

대표논문자료

Min HY, Song SH, Lee B, Kim S, Lee SK (2010) Inhibition of lipopolysaccharide-induced nitric oxide production by antofine and its analogues in RAW 264.7 macrophage cells. Chem Biodivers. 7(2):409-14.

Hong JY, Nam JW, Seo EK, Lee SK (2010) Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa. Chem Pharm Bull (Tokyo). 58(2):234-7.

Kim SJ, Min HY, Lee EJ, Kim YS, Bae K, Kang SS, Lee SK (2010) Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells. Phytother Res. 24(2):193-7.

Song SH, Min HY, Han AR, Nam JW, Seo EK, Park SW, Lee SH, Lee SK (2009) Suppression of inducible nitric oxide synthase by (-)-isoeleutherin from the bulbs of Eleutherine americana through the regulation of NF-kappaB activity. Int Immunopharmacol. 9(3):298-302. 

Park EJ, Min HY, Chung HJ, Hong JY, Kang YJ, Hung TM, Youn UJ, Kim YS, Bae K, Kang SS, Lee SK (2009) Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer Lett. 277(2):133-40. 

Park EJ, Choi SJ, Kim YC, Lee SH, Park SW, Lee SK (2009) Novel small molecule activators of beta-catenin-mediated signaling pathway:structure-activity relationships of indirubins. Bioorg Med Chem Lett. 19(8):2282-4. 

Min HY, Kim MS, Jang DS, Park EJ, Seo EK, Lee SK (2009) Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells. Int Immunopharmacol. 9(7-8):844-9. 

Son SH, Kim MJ, Chung WY, Son JA, Kim YS, Kim YC, Kang SS, Lee SK, Park KK (2009) Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. Cancer Lett. 280(1):86-92. 

Jeong LS, Tosh DK, Choi WJ, Lee SK, Kang YJ, Choi S, Lee JH, Lee H, Lee HW, Kim HO (2009) Discovery of a new template for anticancer agents: 2'-deoxy-2'-fluoro-4'-selenoarabinofuranosyl-cytosine (2'-F-4'-seleno-ara-C). J Med Chem. 10;52(17):5303-6.

Kang YJ, Park KK, Chung WY, Hwang JK, Lee SK (2009) Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. J Pharmacol Sci. 111(3):276-84.

Jeong LS, Pal S, Choe SA, Choi WJ, Jacobson KA, Gao Z, Klutz AM, Hou X, Kim HO, Lee HW, Lee SK, Tosh DK, and Moon HR (2009) Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. J. Med. Chem., 51: 6609-6613

Lee CK, Park K, Hwang J, Lee SK, Chung W (2009) Extract of Prunus persica flesh (PPFE) improves chemotherapeutic efficacy and protects against nephrotoxicity in cisplatin-treated mice. Phytotherapy Res., 23: 999-1005.

Min HY, Kim MS, Jang DS, Park EJ, Seo EK, Lee SK (2009) Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) Int Immuno pharmacol. 9: 844-849. 

Son SH, Kim MJ, Chung WY, Son JA, Kim YS, Kim YC, Kang SS, Lee SK, Park KK (2009) Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase Cancer Lett., 280: 86-92.

Pal S, Choi WJ, Choe SA, Heller CL, Gao ZG, Chinn M, Jacobson KA, Hou X, Lee SK, Kim HO, Jeong LS (2009) Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. Bioorg. Med. Chem. 17: 3733-3738. 

Kim SJ, Min HY, Lee EJ, Kim YS, Bae KH, Kang SS, Lee SK (2009) Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells. Phytotherapy Res., 22: 223-227.

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