SEOUL NATIONAL UNIVERSITY
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박성혁사진
  • 성명 박성혁
  • 직위 교수
  • 학과 제약학과
  • 전공 대사단백체 시스템생물학/천연물과학
  • 사무실 143-309
  • 홈페이지 http://sparklab.snu.ac.kr
  • 이메일 psh@snu.ac.kr
  • 연락처 880-7831/880-7834

학  력

2001. 6 - 2005. 2 : Harvard Medical School, Boston, MA / PhD
1996. 9 - 2001. 5 : University of Illinois at Chicago IL / PhD
1996. 3 - 1996. 8 : Seoul Municipal University / Lecturer
1992. 3 - 1996. 2 : College of Pharmacy , Seoul National University / MS
1988. 3 - 1992. 2 : College of Pharmacy , Seoul National University / BS

주요경력

2001.05 ~ 2005.02 : HARVARD MEDICAL SCHOOL (박사후과정)
2005.03 ~ 2011.08 : 인하대학교 의과대학 (조.부교수)
2008.07 ~ 2008.09 : HARVARD MEDICAL SCHOOL (방문조교수)
2011.01 ~    : Biomolecules and Therapeutics (Editorial Board)
2011.01 ~    : Archives of Pharmacal Research (Associate Editor)
2011.9.1 ~ present : Seoul National University (부교수)

주요관심연구분야

자기공명장치를 이용하여 IP3 수용체와 같은 단백질에 대한 원자적 수준에서의 구조적 기능적 연구를 수행할 뿐만 아니라 주요 질병에 대한 새로운 진단법이나 천연물등 외부자극에 의한 생체내 반응평가법 개발을 위하여 대사체학과 단백체학에 기반한 시스템 생물학 연구를 진행해 나가고 있다.

대표논문자료

Jinho Kang, Sunmi Kang, Seung Hyun Yoo, Sunghyouk Park, Identification of residues 
participating in the interaction between an intraluminal loop of Inositol 1,4,5-
trisphosphate receptor and a conserved N-terminal region of chromogranin B, 
Biochimica et Biophysica Acta, 1774, 502-509 (2007)

Sunmi Kang, Jinho Kang, Hyuknam Kwon, Dominique Frueh, Seung Hyun Yoo, Gerhard 
Wagner, and Sunghyouk Park, Effects of redox potential and Ca2+ on Inositol 1,4,5 trisphosphate receptor L3-1 loop region: implications for receptor regulation, J. Biol Chem., 283, 25567-25575 (2008)

Jinho Kang, Sunmi Kang, Hyuk Nam Kwon, Wen He, Sunghyouk Park, Distinct interactions between ubiquitin and the SH3 domains involved in immune signaling, Biochimica et Biophysica Acta, 1784, 1335-1341 (2008)

Jinho Kang, Moon-Young Choi, Sunmi Kang, Hyuk Nam Kwon, He Wen, Chang Hoon Lee 
Minseok Park2, Susanne Wiklund, Hyo Jin Kim, Sung Won Kwon, and Sunghyouk Park, Application of an 1H-NMR metabolomics approach combined with Orthogonal Projections to Latent Structures-Discriminant Analysis as an efficient tool for discriminating between Korean and Chinese herbal medicines, J. Agric. Food Chem, 56, 11589-11595 (2008)

He Wen, Sung Soo Yoo, Jinho Kang, Hee Goo Kim, Seok Jeong, Jung Il Lee, Hyuk Nam Kwon, Sunmi Kang, Don-Haeng Lee, Sunghyouk Park, A New NMR-based metabolomics approach for the diagnosis of biliary tract cancer, J. Hepatol.,52,228-233, (2010)

Koh Takeuchi, Zhen-Yu J. Sun, Sunghyouk Park*, Gerhard Wagner*. Auto-inhibitory interaction in the multidomain adaptor protein Nck: possible roles in improving specificity and functional diversity, Biochemistry, 49, 5634-5641 (2010) (*Corresponding authors)

Sunmi Kang, Jinho Kang, Hyuknam Kwon, Dominique Frueh, Seung Hyun Yoo, Gerhard Wagner, and Sunghyouk Park, Global dynamic conformational changes in the Inositol-
1,4,5-trisphosphate receptor suppressor domain induced by the two lobes of calmodulin, FASEB Journal 25, 840-850 (2011)

Hyuk Nam Kwon, Min Ah Kim, He Wen, Sunmi Kang, Myung-Joo Choi, Hee Seung Lee, In Suh Park, Soon Sun Hong, Sunghyouk Park, Predicting idiopathic toxicity of the anticancer agent cisplatin with a pharmacometabolomic approach, Kidney International 79, 529-537 (2011) 

He Wen, Mi Young Lee, Yonghyun Song, Sangho Moon , Sunghyouk Park, Combined genomic-metabolomic approach for the differentiation of geographical origins of natural products: deer antlers as an example, J. Agric. Food Chem, 59, 6339-6345 (2011)

Hey-ji Yang, Myung-Joo Choi, He Wen, Hyuk Nam Kwon, Kyung Hee Jung, Sang-Won Hong, Jun Mee Kim, Soon-Sun Hong, Sunghyouk Park, An effective assessment of simvastatin-induced toxicity with NMR-based metabonomics approach, Plos One 6, e16641 (2011)

석•박사지도논문

1. Homer3 EVH1 domain과 IP3R suppressor domain 간의 상호작용의 기전에 대한 연구 (2009.08)
2. 세포 내 칼슘 유리 통로와 FKBP12간의 상호작용에 대한 구조적 연구 (2009.08)
3. Calcium에 의존적인 Inositol 1,4,5-trisphosphate receptor의 CaM binding site에 대한 연구 (2010.02)
4. Ryanodine receptor type 1의 calmodulin like domain에 대한 구조적 특징 연구 (2011.02)
5. 핵자기공명분광법 대사체학을 이용한 simvastatin 독성의 효과적인 평가 (2011.02)

관심연구분야

연구실Fax

880-0649

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