SEOUL NATIONAL UNIVERSITY
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학  력

Ph.D., University of Georgia (1992)
M.S., Seoul National University (1986)
B.S., Seoul National University (1984)

주요 경력

1993 - 1995: Postdoc, National Institutes of Health, USA
1995 - 2013: Professor, Ewha Womans University
2008 - 2013: Principal Investigator of WCU Type 1 Project of NRF, Korea
2013 - Present: Professor, Seoul National University

주요관심연구분야

1) 아데노신 수용체 리간드 개발 연구
2) DNA methyltransferase 저해제 개발연구
3) S-adenosylhomocysteine hydrolase 의 mechanism-based inhibitors 개발 연구
4) AIDS, Herpes, B/C형간염 치료제 개발
5) 차세대 셀레노핵산의 개발

대표논문자료

1. Yoon. J. S., Kim G. D., Jarhad. D. B,. Kim. H. R., Shin. Y. S., Qu. S. H., Sahu. P. K., Kim. H. O., Lee. H. W., Wang. S. B., Kong. Y. J., Chang. T. S., Ogando. T. S., Kovacikova. K., Snijder. E. J., Posthuma. C. C., van Hemert. M. J., Jeong. J. S*., Design, Synthesis and Anti-RNA Activity of 6’-Fluorinated-Aristeromycin Analogues. J. Med. Chem., 2019, 62, 13, 6346.

  2. Yoon. J. S., Jarhad. D. B., Kim. G. D., Nayak. A., Zhao L. X., Yu. J. H., Kim. H. R., Lee. J. Y., Mulamoottil. V. A., Chandra. G., Byun. W. S., Lee. S. K., Kim. Y. C., Jeong. L. S.*, Design, Synthesis and Anticancer Activity of Fluorocyclopentenyl-purines and -pyrimidines. Eur. J. Med. Chem., 2018, 155, 406.

3. Yu. J. H., Ahn. S. Y., Kim. H. J., Lee. M. Y., Ahn. S. J., Kim J. M., Jin. S. H., Lee. E. Y., Kim. G. D., Cheong. J. H., Jacobson. K. A*., Jeong. L. S*., Noh. M. S*., Polypharmacology of N6-(3-iodobenzyl)adenosine-5’-N-methyl-uronamide (IB-MECA) and related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential. J. Med. Chem. 2017, 60, 17, 7459.

4. Kim. G. D., Yoon. J. S., Jarhad. D.B., Shin. Y.S., Majik. M. S., Mulamoottil. V. A. Hou. X. Y., Qu. S. H., Park. J. Y., Baik. M. H., Jeong. L. S*., Asymmetric Synthesis of (-)-6’-β-Fluoro-aristeromycin  via Stereoselective Electrophilic Fluorination. Org. Lett. 2017, 19, 21, 5732.

5. Yu. J. H., Zhao. L. X., Park. J. M., Lee. H. W., Sahu. P. K., Cui. M. H., Moss. S. M., Hammes. Eva., Warnick. E., Gao. Z. G., Noh. M. S., Choi Sun*., Ahn. H. Chul., Choi. J. W., Jacobson. K. A*., Jeong L. S*.,  N6-Substituted 5’-N-Methylcarbamoyl-4’-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation. J.Med.Chem. 2017, 60, 8, 3422.

6. Chandra. G., Moon. Y. W., Lee. Y. J., Jang. J. Y., Song. J. Y., Nayak. A., Oh. K. W., Mulamoottil. V. A., Sahu. P. K., Kim. G. D., Chang. T. S*., Noh. M. S*., Lee. S. K*., Choi. S*., Jeong. L. S*., Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities. J. Med. Chem. 2015, 58, 12, 5108

7. Sahu. P. K., Umme. T., Nayak. A., Kim. G. D., Noh. M. S*., Lee. J. Y*., Kim. D. D*., Jeong. L. S*., Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents. J. Med. Chem. 2015, 58, 21, 8734.

8. Kim. G. D., Cho. Y. J., Sahu. P. K., Yu. J. H., Qu. S. H., Lee. D. J., Jeong. L. S*., Stereoselective Synthesis of D-5-Homo-4-selenoribose as a Versatile Intermediate for 4’-Selenonucleosides. Org. Lett. 2015, 17, 18, 4636.

9. Sahu. P. K., Kim. G. D., Yu. J. H., Ahn. J. Y., Song. J. Y. Choi. Y. J. Jin. X., Kim. J. H., Lee. S. K., Park. S. H., Jeong. L. S., Stereoselective Synthesis of 4'-Selenonucleosides via Seleno-Michael Reactionas Potent Antiviral Agents. Org. Lett. 2014, 16, 21, 5796.

10. Yu. J., Kim. J.-H., Lee. H. W., Alexander. V., Ahn. H.-C., Choi. W. J., Choi. J., Jeong. L. S*., New RNA Purine Building Blocks, 4’-Selenopurine Nucleosides: First Synthesis and Unusual Mixture of Sugar Puckerings. Chemistry-A European Journal, 2013, 19, 5528.

11. Zuo. W., Huang. F., Chiang. Y. J., Li. M., Du. J., Ding. Y., Zhang. T., Lee. H. W., Jeong. L. S*., Chen. Y., Deng. H., Feng. X. H., Luo. S., Gao. C., Chen. Y. G., C-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-beta Type II Receptor, Molecular Cell, 2013, 49, 499.

12. Kang. H. J., Voleti. B., Hajszan. T., Rajkowska. G., Stockmeier. C. A., Licznerski. P., Lepack. A., Majik. M. S., Jeong. L. S., Banasr. M., Son. H., Duman. R. S., Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nature Medicine, 2012, 18, 1413.

13. Luo. Z., Yu. G., Lee. H. W., Li. Li., Wang. L,, Yang. D., Pan. Y., Ding. C., Qian. J., Wu. L., Chu. Y., Yi. J., Wang. X., Sun. Y., Jeong. L. S*., Jia. L., The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. Cancer Res. 2012, 72, 13, 3360.

14. Hou. X., Majik. M. S., Kim. K., Pyee. Y., Lee. Y., Alexander. V., Chung. H. J., Lee. H. W., Chandra. G., Lee. J. H., Park. S. G., Choi. W. J., Kim. H. O., Phan. K., Gao. Z. G., Jacobson. K. A., Choi. S., Lee. S. K., Jeong. L. S*., Structure-Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A2A and A3 Adenosine Receptor Ligands. J. Med. Chem. 2012, 55, 342.

15. Chandra. G., Majik. M. S., Lee. J. Y., Jeong. L. S*., Stereoselective synthesis of fluoro-homoneplanocin A as a potential antiviral agent. Org. Lett. 2012, 14, 8, 2134.

16. Choi. W. J., Chung. H. J., Chandra. G., Alexander. V., Zhao. L. X., Lee. H. W., Nayak. A., Majik. M. S., Kim. H. O., Kim. J. H., Lee. Y. B., Ahn. C. H., Lee. S. K., Jeong. L. S*., Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity, J. Med. Chem. 2012, 55, 4521.

17. Lee. Y., Jeong. L. S., Choi. S., Hyeon. C., Link between allosteric signal transduction and functional dynamics in a multi-subunit enzyme: S-adenosylhomocysteine hydrolase. J. Am. Chem. Soc. 2011, 133, 19807.

18. Choi. I. Y., Lee. J. C., Ju. C., Hwang. S., Cho. G. S., Lee. H. W., Choi. W. J., Jeong. L. S*., Kim. W. K*., A3 Adenosine Receptor Agonist Reduces Brain Ischemic Injury and Inhibits Inflammatory Cell Migration in Rats. Am. J. Pathol.  2011, 179, 4, 2042.

19. Lee. H. W., Nam. S. K., Choi. W. J., Kim. H. O., Jeong. L. S*., Stereoselective Synthesis of MLN4924, an Inhibitor of NEDD8-activating Enzyme. J. Org. Chem. 2011, 76, 9, 3557.

20. Lee. K. M., Choi. W. J., Lee. Y., Lee. H. J., Zhao. L. X., Lee. H. W., Park. J. G., Kim. H. O., Hwang. K. Y., Heo. Y.-S., Choi. S., Jeong. L. S*., X-ray Crystal Structure and Binding Mode Analysis of Human S-Adenosylhomocysteine Hydrolase Complexed with Novel Mechanism-based Inhibitors, Halo-neplanocin A Analogues. J. Med. Chem. 2011, 54, 4, 930.

21. Alexander. V., Choi. W. J., Chun. J., Kim. H. O., Jeon. J. H., Tosh. D. K., Lee. H. W., Chandra. G., Choi. J., Jeong. L. S*., A New DNA Building Block, 4′-Selenothymidine: Synthesis and Modification to 4′-Seleno-AZT as a Potential Anti-HIV Agent. Organic Lett. 2010, 12, 10, 2242.

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