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학  력

1982년 – 1986년 : 서울대학교 농과대학 농화학 농학사
1986년 – 1988년 : 서울대학교 농과대학 농화학 대학원 농학석사
1992년 – 1995년 : 미국 테네시주립대학 생화학 이학석사
1996년 – 2000년 : 미국 노스캐롤라이나대학 약리학 이학박사


2013년 3월 – 현재 : 서울대학교 약학대학 약학과 교수
2011년 7월 - 현재 : 서울대학교 약학대학 약학과장 
2010년 11월 - 현재 : 한국과학기술 한림원 준회원(의약학부)
2009년 9월 – 2013년 2월 : 서울대학교 약학대학 약학과 부교수
2001년 11월 - 2009년 8월 : 서울대학교 의과대학 의학과 조/부교수
2001년 1월 – 2001년 10월 : 미국 Memorial Sloan-Kettering Cancer Center 박사후연구원


1. Dynamics and Mechanisms of Cellular Functions (adhesion, morphology, migration, and invasion) in 2D or 3D
2. Communication between (tumor) cells and microenvironments
3. Development of a small synthetic compound as an anti-TM4SF5 inhibitor: anti-tumor reagent


1. Jung O, Choi YJ, Kwak TK, Kang M, Lee MS, Ryu J, Kim HJ, Lee JW. The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation. 2013. BBA-Mol. Cell Res. 1833(3):629-642. PMID: 23220047 

2. Jung O, Choi S, Jang SB, Lee SA, Lim ST, Choi YJ, Kim HJ, Kim DH, Kwak TK, Kim H, Kang M, Lee MS, Park SY, Ryu J, Jeong D, Cheong HK, Kim HJ, Park KH, Lee BJ, Schlaepfer DD, Lee JW. Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci. 2012. 125(Pt 24):5960-5973. PMID: 23077174

3. Kwak TK, Lee MS, Ryu J, Choi YJ, Kang M, Jeong D, Lee JW. Cell adhesion-dependent serine 85 phosphorylation of paxillin modulates focal adhesion formation and hepatic migration via association with the C-terminal tail domain of talin. J Biol Chem. 2012 Aug 10;287(33):27499-27509. PMID: 22761432

4.Kang M, Choi S, Jeong SJ, Lee SA, Kwak TK, Kim H, Jung O, Lee MS, Ko Y, Ryu J, Choi YJ, Jeong D, Lee HJ, Ye SK, Kim SH, Lee JW. Cross-talk between TGFβ1 and EGFR signaling pathways induces TM4SF5 expression and epithelial-mesenchymal transition. Biochem J. 2012. 443(3):691-700. PMID: 22292774

5. Kim H, Kang M, Lee SA, Kwak TK, Jung O, Lee HJ, Kim SH, and Lee JW, TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity. Biochim Biophys Acta, 2010. 1803(8):975-982. PMID: 20399237

6. Lee SA, Kim YM, Kwak TK, Kim HJ, Kim S, Ko W, Kim SH, Park KH, Kim HJ, Cho M, and Lee JW, The extracellular loop 2 of TM4SF5 inhibits integrin alpha2 on hepatocytes under collagen type I environment. Carcinogenesis, 2009. 30(11):1872-1879. PMID: 19789264

7. Lee SA, Ryu HW, Kim YM, Choi S, Lee MJ, Kwak TK, Kim HJ, Cho M, Park KH, Lee JW. Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative. Hepatology. 2009. 49(4):1316-25. PMID: 19177595 

8. Choi S, Lee SA, Kwak TK, Kim HJ, Lee MJ, Ye SK, Kim SH, Kim S, Lee JW. Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. Blood. 2009. 113(8):1845-55. PMID: 19036703

9. Kim YB, Choi S, Choi MC, Oh MA, Lee SA, Cho M, Mizuno K, Kim SH, Lee JW. Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex. J Biol Chem. 2008. 283(15):10089-96. PMID: 18252715

10. Lee SA, Lee SY, Cho IH, Oh MA, Kang ES, Kim YB, Seo WD, Choi S, Nam JO, Tamamori-Adachi M, Kitajima S, Ye SK, Kim S, Hwang YJ, Kim IS, Park KH, Lee JW. Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. J Clin Invest. 2008. 118(4):1354-66. PMID: 18357344

11. Oh MA, Kang ES, Lee SA, Lee EO, Kim YB, Kim SH, Lee JW. PKCdelta and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin alpha5 but not its tailless mutant. J Cell Sci. 2007. 120(Pt 15):2717-30. PMID: 17646675

12. Kim YB, Yu J, Lee SY, Lee MS, Ko SG, Ye SK, Jong HS, Kim TY, Bang YJ, Lee JW. Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities. J Biol Chem. 2005. 280(31):28357-64. PMID: 15961394

13. Lee MS, Kim TY, Kim YB, Lee SY, Ko SG, Jong HS, Kim TY, Bang YJ, Lee JW. The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells. Mol Cell Biol. 2005. 25(16):6921-36. PMID: 16055706


1. 이신애 (2010년 2월) Human Heptic Tumorigenesis and Metastasis: Role of TM4SF5-integrin cooperation and its antagonist development
2. 김용배 (2008년 2월) Transmodulation between cell adhesion-dependent epigenetic gene regulation and cell function in gastric carcinoma cells

1. 최윤주 (2013년 2월) The role of Transmembrane 4 L6 family member 5 (TM4SF5) in zebrafish development
2. 정도영 (2012년 8월) Study on functions of the TM4SF5 intracellular domains
3. 정외선 (2011년 8월) TM4SF5-mediated FAK activation for an enhanced cell migration and invasion 
4. 김현중 (2011년 2월) Regulation of cell cycle progression via tetraspanin TM4SF5
5. 곽태경 (2010년 2월) Actin reorganization by cell adhesion-dependent O-glycosylation of paxillin
6. 최수용 (2009년 2월) Angiogenic trait of tetraspan TM4SF5 via crosstalks with integrin alpha 5
7. 오민아 (2008년 2월) Regulation of cell-cell adhesion by integrin-mediated signal transduction to PKCdelta and cofilin
8. 강은실 (2008년 2월) Competitive control of pancreatic beta cell fate via O-glycosylation and phosphorylation on Ser473 of Akt1
9. 이성률 (2006년 2월) TM4SF5-mediated regulation of integrin signaling transduction
10. 이미숙 (2005년 2월) Signal transduction underlying gastric carcinoma cell spreading





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