SEOUL NATIONAL UNIVERSITY
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이승희사진
  • 성명 이승희
  • 직위 부교수
  • 학과 약학과
  • 전공 약물학(분자세포생물학)
  • 사무실 143-306
  • 홈페이지
  • 이메일 leeseung@snu.ac.kr
  • 연락처 880-2478/880-2518

학  력

2001 년 : 전남대학교 약학대학 / 학사
2006 년 : Baylor College of Medicine / 박사

주요경력

2006년 5월-2010년 6월: Baylor College of Medicine, Post Doctoral Associate
2010년 7월-2011년 3월: Oregon Health & Science University, Post Doctoral Associate 
2011년 4월-2012년 2월: Oregon Health & Science University, Research Assistant Professor
2012년 3월-2016년 2월: 서울대학교 약학대학 조교수
2016년 3월-현재: 서울대학교 약학대학 부교수

주요관심연구분야

- 배아 중추신경발달 유전자조절 네트워크
- 줄기세포 후성유전조절
- 대사 및 암화 유전자조절 네트워크

대표논문자료

- Kim J, Lee B, Kim DH, Yeon JG, Lee J, Park Y, Lee Y, Lee SK, Lee S*, Lee JW*. UBE3A suppresses overnutrition-induced expression of the steatosis target genes of MLL4 by degrading MLL4. Hepatology. 2019 Mar;69(3):1122-1134

- Kim J, Choi TI, Park S, Kim MH, Kim CH, Lee S*. Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains. Development. 2018 Sep 3;145(17). (recommended by Faculty of 1000 Biology)

- Lee B, Kim J, An T, Kim S, Patel EM., Raber J, Lee SK, Lee S* & Lee JW*. Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons. Nature Communications, 2018 May 23; 9:2026

- Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S*, Lee JW*. Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2. Cell Rep. 2016 Nov 1;17(6):1671-1682.

- Lee B, Lee S*, Lee SK, Lee JW*. The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons. Development. 2016 Oct 15;143(20):3763-3773

- Clovis Y, Seo SY, Kwon JS, Rhee JC, Yeo S, Lee JW, Lee S*, and Lee SK*. Chx10 consolidates V2a interneuron identity through two distinct gene repression modes. Cell Reports, 2016 Aug 9;16(6):1642-52

- Nam H, Lee S*. Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons. Development, 2016 Jul 1;143(13):2334-43 (recommended by Faculty of 1000 Biology)

- Seo SY, Lee B, and Lee S*. Critical roles of the LIM domains of Lhx3 in recruiting coactivators to the motor neuron-specifying Isl1-Lhx3 complex. Mol Cell Biol, 2015 Oct 15;35(20):3579-89. (highlighted in Spotlight as a hot paper)

- Thiebes KP, Nam H, Cambronne XA, Shen R, Glasgow SM, Cho H, Kwon J, Goodman RH, Lee JW, Lee S*, and Lee SK*. miR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3. Nature Communications, 2015 Jul 27;6:7718.

- Kim DH, Rhee JC, Yeo S, Shen R, Lee SK, Lee JW, and Lee S*. Crucial roles of MLL3 and MLL4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis. Hepatology 61, 1012-1023, 2015

- Cho HH, Cargnin F, Kim Y, Lee B, Kwon RJ, Nam H, Shen R, Barnes AP, Lee JW,
Lee S*, and Lee SK*. Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. Plos Genetics 10, e1004280, 2014.

- Kim SG, Lee B, Kim DH, Kim J, Lee S*, Lee SK, and Lee JW*. Control of energy balance by a hypothalamic gene circuitry involving two nuclear receptors, NOR1 and GR. Mol Cell Biol 33, 3826-34, 2013

- Lee S*, Shen R, Cho HH, Kwon RJ, Seo SY, Lee JW, and Lee SK*. Stat3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex. Proc Natl Acad Sci USA 110, 11445-50, 2013

- Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK. Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs. Proc Natl Acad Sci USA 109(9), 3383-8, 2012

- Lee S, Lee JW, and Lee SK. UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Developmental Cell 22, 1-13, 2012

- Lee S and Lee.SK. Crucial roles of histone-modifying enzymes in mediating neural cell-type specification. Curr Opin Neurobiol 20:29-36, 2010

- Lee S, Lee B, Lee JW, and Lee SK. Retinoid signaling and Ngn2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron 62, 641-54, 2009

- Joshi K, Lee S, Lee B, Lee JW, and Lee SK. LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron 61, 839-51, 2009

- Lee S, Roeder RG, and Lee JW. Roles of histone H3-lysine 4 methyltransferase complexes in NR-mediated gene transcription. Prog Mol Biol Transl Sci 87C:343-382, 2009

- Lee JK, Kim DH, Lee S, Yang Q, Lee DK, Lee SK, Roeder RG, and Lee JW. A tumor suppressive coactivator complex of p53 containing histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci USA 106, 8513-8, 2009

- Lee S, Lee B, Joshi K, Pfaff S, Lee JW, and Lee SK. A regulatory network to segregate spinal neuronal subtypes. Developmental Cell 14, 877-89, 2008

- Lee S, Lee J, Lee SK, and Lee JW. Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferase MLL3 and MLL4 to the liver X receptors. Mol Endocrinol 22, 1312-9, 2008

- Lee S, Lee DK, Dou Y, Lee J, Lee B, Kwak E, Kong YY, Lee SK, Roeder RG, Lee JW. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci USA 103,15392-7,2006

- Dou Y, Milne TA, Ruthenburg AJ, Lee S, Lee JW , Verdine GL, Allis CD, Roeder RG. Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol 13, 713-9, 2006

- Lee S, Lee DK, Choi E, Lee JW. Identification of a functional vitamin D response element in the murine Insig-2 promoter and its potential role in the differentiation of 3T3-L1 preadipocytes. Mol Endocrinol 19,399-408, 2005 

 

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