SEOUL NATIONAL UNIVERSITY
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서영준사진

학  력

- Ph.D. (1990) University of Wisconsin-Madison 
- Postdoc (1990-1992) Massachuestts Institute of Technology (MIT)

주요경력

- Yale 대학교 의대 조교수 (1992-1996)
- 현 한국과학기술 한림원 정회원
- 이달의 과학기술자상 (2006. 6)
- 현 Carcinogenesis (Oxford Univ. Press) Editorial board member
- 현 Molecular Carcinogenesis (John Wiley & Sons) Associate Editor
- 현 Cancer Prevention Research (AACR) Editorial board member
- 현 International J. Cancer (Wiley & Sons) Editorial board member
- 현 Mutation Research (Elsevier Science) Editorial board member
- 현 Cancer Letters (Elsevier Science) Editorial board member
- 현 J. Environ. Pathol. Toxicol. Oncol. (Begel Science) 
Associate Editor
- 현 International J. Oncology Editorial board member
- 현 Food & Chemical Toxicology (Elsevier) Editorial board member
- 현 Current Cancer Therapy Review (Bentham Science) Editorial 
board 
- 현 Biofactors (Wiley & Sons) Editorial board member
- 현 Genes & Nutrition (Springer Verlag) Editorial Board member
- 현 Molecular Nutrition & Food Research (Wiley-VCH) Editorial 
board member
- 현 Molecular Medicine Report: Editorial board member
- 현 Genes & Environment (Springer Verlag) Editorial board member
- The 9th Int'l Confrence on Mechanisms of Antimutagenesis & 
Anticarcinogenesis (Dec. 1-5, 2007) 조직위원장
- 현 국제 환경돌연변이원학회 한국대표 (Councillor
- 현 대한암협회 이사
- 현 대한암예방학회 학술이사
- 현 대한 생화학 분자생물학회 이사
- 현 한국분자세포생물학회 학술위원장
- 국제세포생물학회 (ICCB 2008) 학술위원장

주요관심연구분야

1. 천연물 및 합성유도체들에 의한 화학적 암예방(cancer chemo-prevention)
2. 염증과 암 (Inflammation and cancer)
3. 산화적 스트레스에 의한 DNA 손상 및 세포사멸 유도기전 연구 및 방어물질 탐색
4. 발암원 및 돌연변이원 물질들의 생화학적 적용기전연구: 생체내 대사활성화(metabolic activation) 및 DNA와의 공유결합 부가물(DNA adducts) 형성

대표논문자료

Lee HG, Li MH, Joung EJ, Na HK, Cha YN, Surh YJ, Nrf2-Mediated Heme Oxygenase-1 Upregulation as Adaptive Survival Response to Glucose Deprivation-Induced Apoptosis in HepG2 Cells. ANTIOXIDANTS & REDOX SIGNALING 13, pp.1639-1648 (2010.12)

Kim MJ, Kim DH, Na HK, Surh YJ, TNF-alpha Induces Expression of Urokinase-
type Plasminogen Activator and Beta-catenin Activation through Generation of ROS in Human Breast Epithelial Cells. BIOCHEMICAL PHARMACOLOGY 80, pp.2092-2100 (2010.12)

Surh YJ, Bode AM, Dong ZG, Breaking the NF-kB and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis. CANCER PREVENTION RESEARCH 3, pp. 1379-1381 (2010.11)

Lee HH, Park SA, Almazari I, Kim EH, Na HK, Surh YJ, Piceatannol Induces Heme Oxygenase-1 Expression in Human Mammary Epithelial Cells through Activation of ARE-driven Nrf2 Signaling. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 501, pp.142-150 (2010.09)

Son PS, Park SA, Na HK, Jue DM, Kim S, Surh YJ, Piceatannol, a Catechol-type Polyphenol, Inhibits Phorbol Ester-induced NF-kappa B Activation and Cyclooxygenase-2 Expression in Human Breast Epithelial Cells: Cysteine 179 of IKK beta as a Potential Target. CARCINOGENESIS 31, pp.1442-1449 (2010.09)

Kim J, Cha YN, Surh YJ, A Protective Role of Nuclear Factor-Erythroid 2-Related Factor-2 (Nrf2) in Inflammatory Disorders. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 690, pp. 12-23 (2010.08)

Collett NP, Amin ARMR, Bayraktar S, Pezzuto JM, Shin DM, Khuri FR, Aggarwal BB, Surh YJ, Kucuk O, Cancer Prevention With Natural Compounds. SEMINARS IN ONCOLOGY 37, pp .258-281 (2010.06)

Kundu JK, Surh YJ, Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis. PHARMACEUTICAL RESEARCH 27, pp. 999-1013 (2010.06)

Kim DH, Kim EH, Na HK, Sun Y, Surh YJ, 15-Deoxy-Delta(12,14)-Prostaglandin J(2) Stabilizes, but Functionally Inactivates p53 by Binding to the Cysteine 277 Residue. ONCOGENE 29(17), pp. 2560-2576 (2010.04)

Shrotriya S, Kundu JK, Na HK, Surh YJ, Diallyl Trisulfide Inhibits Phorbol Ester-Induced Tumor Promotion, Activation of AP-1, and Expression of COX-2 in Mouse Skin by Blocking JNK and Akt Signaling. CANCER RESEARCH 70(5), pp. 1932-1940 (2010.04)

Park SA, Na HK, Kim EH, Cha YN, Surh YJ, 4-Hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of i kappa B kinase: Potential role of reactive oxygen species. CANCER RESEARCH 69, pp. 2416-2424 (2009)

Lee MH, Choi BY, Kundu JK, Shin YK, Na HK, Surh YJ, Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: Eukaryotic elongation factor 1A2 as a potential target. CANCER RESEARCH 69, pp. 7449-7458 (2009)

Kim DH, Kim JH, Kim EH, Na HK, Cha YN, Chung JH, Surh YJ, 15-Deoxy-Delta(12,14) -prostaglandin J(2) upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS. CARCINOGENESIS 30, pp. 645-654 (2009)

Choi JW, Um JY, Kundu JK, Surh YJ, Kim S, Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. CARCINOGENESIS 30, pp. 1638-1644 (2009)

Li, M.-H., Jang, J.-H., Na, H.-K., Cha, Y.-N., and Surh, Y.-J. Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate cysteine ligase in PC12 cells via activation of PI3K and Nrf2 signaling. J. Biol. Chem., 282, pp. 28577-28586 (2007)

Kim, S.-O., Kundu, J.K., Shin, Y.K., Park, J.-H., Cho, M.-H., Kim, T.-Y., and Surh, Y.-J. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase. Oncogene, 24, pp. 2558-2567 (2005)

Lim, S.-Y., Jang, J.-H., Na, H.-K., Lu, S., Rahman, I., and Surh, Y.-J. 15-deoxy- 12,14-prostaglandin J2 protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. J. Biol. Chem., 279, pp. 46263-46270 (2004) 

Surh YJ, Cancer chemoprevention with dietary phytochemicals. NATURE REVIEWS CANCER 3, pp. 768-780 (2003.10) 

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