SEOUL NATIONAL UNIVERSITY
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김상희사진

연구실소개

학  력

Ph.D., University of Pennsylvania

주요관심연구분야

1. 생리활성천연물 및 유도체 합성
2. Combinatorial Chemistry를 이용한 선도물질 개발
3. 기능성물질 설계 합성(DNA Chip, molecular switch)
4. 생체신호전달 조절물질 개발 (Intracellular Signal Transduction Regulator development)

대표논문자료

Dong Jae Baek, Yoon-Sook Lee, Chaemin Lim, Doohyun Lee, Taeho Lee, Jae-Young Lee, Kyoo-A Lee, Won-Jea Cho, Chang-Yuil Kang, and Sanghee Kim "Rational design and evaluation of a branched chain-containing glycolipid antigen that binds to CD1d" Chem.-Asian J. (2010) 

Ji Yeon Lee, Yong Gyu Lee, Jaehwi Lee, Keum-Jin Yang, Ae Ra Kim, Joo Young Kim, Moo-Ho Won, Jongsun Park, Byong Chul Yoo, Sanghee Kim, Won-Jea Cho, and Jae Youl Cho "Akt Cys310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects" J. Bio. Chem, 285 (13), pp. 9932-9948 (2010)

Hye-Young Min, Su-Hyun Song, Boeun Lee, Sanghee Kim, Sang Kook Lee "Inhibition of lipopolysaccharide-induced nitric oxide production by antofine and its analogues in RAW 264.7 macrophage cells" Chem. Biodiv. 7(2), pp. 409-414 (2010)

Wonjang Jeong, Mi Jung Kim, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim, Kye Jung Shin "Substrate-controlled asymmetric total synthesis and structure revision of (+)-Itomanallene A" Angew. Chem. Int. Ed. Engl. 49(4), pp. 752-756 (2010) 

Su Jin Hwang, Ji Hyung Kim, Hye Young Kim, Sanghee Kim, and Doo Hyun Chung "FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration" Laboratory Investigation 90(1), pp. 9-19 (2010)

Sanghee Kim "Synthesis and structural analysis of one-dimensional sp-hybridized carbon chain molecules" Angew. Chem. Int. Ed. Engl. 48(42), pp. 7740-7743 (2009)

Chaemin Lim, Dong Jae Baek, Deukjoon Kim, So Won Youn, Sanghee Kim “Efficient synthesis of (+)-MK7607 and its C-1 epimer via the stereoselective transposition of a tertiary allylic Alcohol" Org. Lett.11(12), pp. 2583-2586 (2009) 

Sanghee Kim, Bogyeong Kim, Jinkyung In “Facile deprotection of bulky (Trialkylsilyl)acetylenes with silver fluoride” Synthesis, pp. 1963-1968 (2009)

Jihee Cho, Yun Mi Lee, Deukjoon Kim, and Sanghee Kim “Design and synthesis of piperidine-containing sphingoid base analogues” J. Org. Chem. 74(10), pp. 3900-3904 (2009)

Byungsook Kim, Miseon Lee, Mi Jung Kim, Hyunjoo Lee, Sanghee Kim, Deukjoon Kim, Minseob Koh, Seung Bum Park and Kye Jung Shin “Biomimetic asymmetric total synthesis of (−)-Laurefucin via an organoselenium-mediated intramolecular hydroxyetherification” J. Am. Chem. Soc. 130(49), pp. 16807-16811 (2008) 

Ye Fu, Sang Kook Lee, Hye-Young Min, Taeho Lee, Jaekwang Lee, Maosheng Cheng and Sanghee Kim "Synthesis and structure-activity studies of antofine analogues as potential anticancer agents" Bioorg. Med. Chem. Lett. 17(1), pp. 97-100 (2007)

석•박사지도논문

[ 박사 ]

Studies toward the Synthesis of Bioactive Natural and Non-natural Products using Enzyme resolution and Metathesis (이태호 / 2005.08)

[ 석사 ]

Studies toward the Synthesis of Fluorescence-Labeled Polyyne Containing Sphingoid Base (유지수 / 2008.02)
Solid-Phase Synthesis of Natural Product-like Polyyne Library (이선우 / 2008.02)
Syntheses and Evaluation of Triazole-Ceramides and Calix-Triazoles using "Click" Chemistry (조민재 / 2008.02)
Design and Synthesis of the Conformationally Constrained Sphingoid Base Analogs (조지희 / 2007.08)
The Cyclic Sulfate Chemistry of Phytosphingosine in the Synthesis of Sphingolipids (이숙진 / 2007.02)
Chemical Reactions and Utilities of Bulky Trialkylsilyl Acetylene and AgF System (강희룡 / 2007.02)
Formal Synthesis of (-)-Lepadiformine (이민희 / 2005.08)
Practical Synthesis of an Immunosuppressive Agent FTY720 (이혜승 / 2005.08)
Asymmetric Syntheses of (-)-Antofine, (-)-Cryptopleurine, and their Derivatives (이은정 / 2005.02)

-최근 3년간 지도논문-

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