SEOUL NATIONAL UNIVERSITY
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김상건사진
  • 성명 김상건
  • 직위 교수
  • 학과 약학과
  • 전공 약물학
  • 사무실 29-313
  • 홈페이지
  • 이메일 sgk@snu.ac.kr
  • 연락처 880-9185/ 880-7840

학  력

Ph.D. Northwestern Univ. Medical School (1989)
M.S. Seoul National University (1985)
B.S. Seoul National University (1982)

주요경력

Faculty Appointments
• 2006 - present : Professor, College of Pharmacy, SNU
• 1999 - 2006 : Associate/Assistance Professor, College of Pharmacy, SNU
• 1992 - 1999 : Associate/Assistance Professor, College of Pharmacy, Duksung Women’s University, Seoul, Korea
• 1990 - 1992 : Assistant Professor (Research)/Research Associate, Institute of Chemical Toxicology, Wayne State University, Detroit, MI, USA

Professional Activities
• 2017 - present : PI, Global Research Laboratory
• 2007 - 2016 : Director, Engineering Research Center (Innovative Drug Research Center for Metabolic and Inflammatory Disease), SNU
• 2001 - 2006 : PI, National Research, SNU
• 2008 - 2011 : Associate Dean, College of Pharmacy, SNU
• 2005 - 2008 : Chairman, Department of Pharmacology, SNU

Major Professional Societies
• 2017 - present : President of Korean Pharmacological Society
• 2017 - present : Vice President of Korean Pharmaceutical Society
• 2005 - present : Editorial Board Members of Journal of Molecular Signaling; Current Patents on Anti-Cancer Drug Discovery; Current Clinical Pharmacology; (1997-2012) Drug Metabolism and Disposition
• 1990 - present : Member of ASBMB; ASPET; SOT of USA

주요관심연구분야

1. 염증 및 대사질환 치료신약 개발
2. Phase Ⅱ 대사효소의 생리작용 및 유전자발현기전의 분자약물학
3. 간경화 치료제 개발
4. 지방세포 분화에 대한 약물학적 연구
5. Gα12 subfamily에 대한 신호 전달 연구 

대표논문자료

Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration. J Clin Invest (2018)>

FXR inhibits endoplasmic reticulum stress-induced NLRP3 inflammasome in hepatocytes and ameliorates liver injury. Cell Rep (2018)>

TH Kim, YW Kim, SM Shin, CW Kim, IJ Yu, and SG Kim. Synergistic hepatotoxicity of N,N-dimethylformamide with carbon tetrachloride in association with endoplasmic reticulum stress, Chem. Biol. Interact. 184, pp. 492-501, (2010) 

Hwahng SH, Ki SH, Bae EJ, Kim HE, Kim SG, Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones. HEPATOLOGY 49, pp. 1913-1925 (2009.06)

Lee SJ, Yang JW, Cho IJ, Kim WD, Cho MK, Lee CH, Kim SG, The gep oncogenes, G alpha(12) and G alpha(13), upregulate the transforming growth factor-beta 1 gene. ONCOGENE 28, pp. 1230-1240 (2009.03)

Cho IJ, Kim SG, A novel mitogen-activated protein kinase phosphatase-1 and glucocorticoid receptor (GR) interacting protein-1-dependent combinatorial mechanism of gene transrepression by GR. MOLECULAR ENDOCRINOLOGY 23(1), pp. 86-99 (2009.01)

Kim YW, Zhao RJ, Park SJ, Lee JR, Cho IJ, Yang CH, Kim SG, Kim SC. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production. Br J Pharmacol. 2008;154(1):165-73

Bae EJ, Yang YM, Kim SG. Abrogation of hyperosmotic impairment of insulin signaling by a novel class of 1,2-dithiole-3-thiones through the inhibition of S6K1 activation. Mol Pharmacol. 2008;73(5):1502-12

Choi, MK, Kim WD, Ki SH, Hwang JI, Choi SD, Lee CH, Kim SG. Role of Ga12/13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor. Mol Cell Biol. 2007;27(17):6195-6208

Bae EJ, Yang YM, Kim JW, Kim SG. Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via AMPK-S6K1 pathway. Hepatology 2007;46:730-739

Ki SH, Choi MJ, Lee CH, Kim SG. Ga12 specifically regulates COX-2 induction by sphingosine 1-phosphate: Role for JNK-dependent ubiquitination and degradation of IkBa. J Biol Chem. 2007;282(3):1938-1947

Ko MS, Lee SJ, Lim JW, Kim SG. Differential effects of the oxidized metabolites of oltipraz on the activation of C/EBPbeta and Nrf2 for GSTA2 gene induction. Drug Metab Dispos. 2006;34:1353-1360

Lee SJ, Yang EK, Kim SG. PPARgamma and RXRalpha Represses the TGFb1Gene via PTEN-Mediated S6K1 Inhibition: Role for Zf9 Dephosphorylation. Mol Pharmacol. 2006;70(1):415-425

Lee SJ, Kim SG. Role of RSK1 in oltipraz-induced phosphorylation of C/EBPbeta for GSTA2 gene transactivation. Mol Pharmacol. 2006;69(1):385-396

Cho IJ, Lee AK, Lee SJ, Lee MG, Kim SG. Repression by oxidative stress of the iNOS and cytokine gene induction in macrophages results from AP-1 and NF-kB inhibition mediated by B-cell translocation gene-1 activation. Free Radic Biol Med. 2005;39(11):1523-1536

Bae EJ, Kim SG. Enhanced C/EBPbeta-LIP production by oltipraz, which accompanies CUGBP1 RNA binding protein activation, leads to inhibition of preadipocyte differentiation. Mol Pharmacol. 2005;68:660-669

관심연구분야

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