SEOUL NATIONAL UNIVERSITY
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375.501 Seminar in Pharmacy 1
This course will consist of lectures given by faculty members, visiting scholars, and graduate students, followed by discussions that will cover the latest trends in research and pharmacy. It is intended for students in the MS program.

375.502 Seminar in Pharmacy 2
As a continuation of the course, Seminar in Pharmacy I, this course will consist of lectures given by faculty members, visiting scholars, and graduate students, followed by discussions that will cover the latest trends in research and pharmacy. It is intended for students in the MS program.

375.503 Instruments in Pharmaceutical Research
This is an introductory course to various instruments widely used in pharmaceutical research. This course includes basic principles of the instruments, their applications, interpretation of data, and sample preparation methods.

375.505 Topics in Pharmaceutical Sciences 1
The course aims to provide students with the latest developments in new drug development in the pharmaceutical industry. International as well as domestic professionals specializing in various fields in biotechnology will be invited to lecture and lead discussions on advanced biopharmaceutical subjects. Topics include target development, gene and protein functions and interactions, biological mechanism of various diseases, immune reactions and Mechanism of bioactive materials. The medium of instruction is English and all presentations and discussions should be in English.

375.506 Topics in Pharmaceutical Sciences 2
The course aims to provide students with the latest developments in new drug development in the pharmaceutical industry. International as well as domestic professionals specializing in various fields in biotechnology will be invited to lecture and lead discussions on advanced pharmaceutical chemistry. Topics include design and synthesis of novel bioactive compounds, natural products chemistry, analysis of bioactive compounds, formulation and preformulation studies, and design of dosage forms for optimizing therapy. The medium of instruction is English and all presentations and discussions should be in English.

375.601 Seminar in Pharmacy 3
This course is intended for the students in Ph D program. The course consists of lectures given by faculty members, visiting scholars, and graduate students. Lectures will be followed by discussion covering the latest trends and advances in research on pharmacy.

375.602 Seminar in Pharmacy 4
As a continuation of Seminar in Pharmacy III, the course is intended for the students in Ph D program. The course consists of lectures given by faculty members, visiting scholars, and graduate students. They will be followed by discussions covering the latest trends and advances in research.

Courses in Pharmaceutical Bioscience Major 

375.510 Topics in Biochemistry
The course will cover progress in modern biochemistry and molecular biology. Selected topics will be discussed.

375.538 Advanced Pharmacal Microbiology
The latest findings and progress in microorganisms associated with the production of pharmaceuticals will be discussed in this course.

375.541 Topics in Pharmaco-Molecular and Cellular Signal Transduction
These days, the cutting-edge technologies responsible for rapid developments in cellular biological and biochemical researches and methodologies result in accumulation of knowledge of cell itself in the levels of molecules and in a format of revealing of cellular mechanisms underlying for regulation of cell functions. In addition to recent textbooks describing the information observed in fast years, this class would be based on review and research papers, for updating the scientific knowledge and methodology of the possible students, probably leading to helping them with concrete understanding of cellular functions and their regulation mechanisms and with connecting or understanding of clinical approaches and information.

375.542 Topics in Pharmaceutical Molecular Biology
The achievement of the completed human genome has been widely utilized as the basis for drug development. Accordingly, novel functions and interactions among a variety of genes and/or proteins will be introduced in this course. Furthermore, newly developed concepts for drug development including the molecular prevention of human diseases and pharmacogenomics will be discussed. The course will also include recent movements in and the future of postgenomic research in pharmaceutical science.

375.642 Advanced Antibiotic Chemistry
This course will cover the chemical structures, action mechanisms, resistance mechanisms, and antibacterial activities of new antibiotics.

375.643A Topics in Immunological Products
This introductory course will cover the latest advances in immunology and their application to new immunological product development.

375.647 Actinomycetal Metabolites and Laboratory
In this course, important metabolites of actinomycetes will be discussed and the isolation and physiological activities of these metabolites will be examined through experiments.

375.648A Topics in Genetics and Genomics
This course covers updated information and research trends in the main subjects of genetics and genomics, with a focus on the applications of genetic and genomics to biotechnology and pharmaceutical sciences. Specific issues include DNA replication, transcription, decoding genetic information, molecular structure, mutation and evolution, genomic analysis and information.

375.737A Topics in Medicinal Immunology
Recent advances and applications in immunology are discussed.

375.783 Molecular Endocrinology
This course will cover the latest advances in biochemistry and molecular biology in terms of modern endocrinology. It will provide the general concepts of modern endocrinology: action mechanisms of hormones, disease and endocrinology, signal transduction pathways leading to cell proliferation, cell cycle control, and programmed cell death. Seminars on selected topics from recent issues of major journals are also planned.

375.795A Advanced Oncology
This course will introduce the characteristics of cancer cells, causes of cancer, principles of carcinogenesis, cellular and molecular mechanisms underlying viral, chemical, and physical carcinogenesis, functions of oncogenes and tumor suppressor genes, and current strategies applied to cancer prevention and therapy.

Courses in Pharmacognosy and Pharmaceutical Analysis Major

375.536 Biosynthesis of Plant Constituents
In this course, the primary and secondary plant metabolites and the biosynthetic pathway of these substances will be discussed.

375.537 Medicinal Plants Taxonomy
General information on the taxonomy of medicinal plants will be covered in this course

375.580 Advanced Pharmaceutical Analysis 1
This course is for the development of physical, chemical, and mathematical models for applications to various theories of compound separations. Emphasis will be placed on the theory of chemical equilibrium in terms of pharmaceutical analysis as well as ionic equilibrium, complex-forming reactions, solvent extraction processes, and all chromatographic applications.

375.582 Analysis of Pharmaceutical Preparation 1
In this course, the entire pharmaceutical manufacturing process from the quantitative and qualitative analysis of raw materials to standardization, manufacturing equipmenting, and final product assays and stability studies will be taught.

375.585 Instrumental Analysis 1
This course will consist of lectures on the theories and applications of NMR, IR, UV, MASS, and other spectroscopy for the analysis of pharmaceuticals.

375.587 Principles of Multifunctional Optical Contrast Agents
This subject deals with synthetic methods and applications of multifunctional optical contrast agents used for cancer diagnosis and monitoring of drug efficacy. As diagnostic non-invasive imaging techniques such as magnetic resonance(MR), positron emission tomography(PET) and single photon emission computed tomography(SPECT) develop relevant contrast agents are being actively developed to improve diagnostic sensitivity and accuracy. Recently nanoparticle-based optical constrast agents are used for drug screening based on optical imaging. Quantum dot, gold and silica nanoparticles are highly sensitive, photostable, noninvasive, and non-ionizing. They are capable of being biocompatible and selectively delivered to specific target molecules by surface functionalization, and this leads to their effective use for cancer diagnosis and relevant anticancer drug screening. The optical contrast agents have intrinsic therapeutic property or can be conjugated to therapeutic agents. This allows for the optical contrast agents to be used as multifunctional agents that enable both diagnosis and therapy simultaneously. This subject provides understanding of fundamental principles involved in syntheses and surface functionalization of optical contrast agents and introduces their applications to drug screening and biomedical field.

375.682 Advanced Pharmaceutical Analysis 2
This course will consist of an introduction to theories on and their applications to up-to-date methods of pharmaceutical analysis as well as a presentation of the new processes and a comparison with the existing methods in order to formulate more reasonable and improved methodology for analysis.

375.684 Analysis of Pharmaceutical Preparation 2
The principles and applications of the separative analysis of each component of compounded pharmaceuticals and selective analysis using specific reactions will be considered in this course. Emphasis will be placed on the particular analytical procedures and techniques of official methods of pharmaceutical analysis.

375.686 Instrumental Analysis 2
The fundamental theories of chromatographic separation and quantitation of pharmaceuticals will be taught in this course.

375.696 Studies in Pharmacoproteomics
This class contains actually everything a researcher would try to find in pharmacoproteomics field such as deep theory of instruments, background knowledge, practical protocols, and published data. Also it would be a precious information tool for the researchers who study the proteome related field. By focusing on what is currently issued, graduate students will be able to grasp the available information filtered from numerous primary literatures at the end of the class.

375.697 Natural Product Derived Pharmaceuticals 1
This course covers all aspects of natural products as pharmaceuticals including both plant derived and microbial derived.

375.698 Natural Product Derived Pharmaceuticals 2
An in-depth discussion of recent advanced in knowledge and scientific techniques of natural products as pharmaceuticals including both plant derived and microbial derived

375.796 Screening Methods for Bioactive Natural Products 1
This course provides lectures, discussions, and laboratory experiments on principles for methods to screen compounds with a variety of bioactivity from natural sources.

375.797 Screening Methods for Bioactive Natural Products 2
This course will provide lectures on the principles for methods to screen compounds with various bioactivity from natural sources and laboratory experiments.

375.798 Chemical Structure Analysis of Medicinal Plant Constituents
In this course, students will discuss techniques used for the identification and determination of the structures of substances of natural origin. Discussion topics include physical methods and spectroscopic techniques of structure elucidation.

375.799 Chemistry in Pharmacognosy and Laboratory
This course will cover a comprehensive consideration of the chemistry and pharmacology of plant constituents that are important because of their biological activities. Included will be the bread classes, alkaloids, terpenoids, steroids, flavonoids, and other related groups.

375.800 Advanced Pharmacognosy
This course will cover an in-depth discussion of recent advances in our knowledge of plant and animal materials with biological properties of interest to pharmaceutical scientists.

375.805 Preservation of Natural Resources
This course will offer the origin, classification, distribution, and biological activities of natural pharmaceutical plants.

375.811 Methods in Bioactive Natural Products Research 1
This course will provide lectures on the screening of natural products for biological activities, instruction of pre-screening methods, screening methods to assay certain natural product activities, isolation of active compounds using activity-guided fractionation, and structural elucidation. The animal cell and plant tissue culture systems will be introduced as techniques for enhancing the yield of secondary products

375.812 Methods in Bioactive Natural Products Research 2
This course will provide lectures on the methods to isolate pure compounds with various bioactivity from natural sources. The major subjects will include carcinogens, anti-cancer, anti-inflammatory, anti-conceptive, antibacterial agents, radioimmune assay, affinity chromatography, prostaglandins, phytoalexines, phytohormones, and pheromones.

Courses in Pharmacology Major 

375.513 Advanced Pharmacology 1 and Laboratory
This course will cover the action of autonomic and cardiovascular drugs at the cellular level and the current concepts of the mechanism of drug action.

375.514 Advanced Pharmacology 2 and Laboratory
This course will cover the current research trends, new developments in drugs and pharmacodynamic concepts, and the mechanism of the action of cardiovascular drugs, centrally acting drugs, and chemotherapeutic agents.

375.516 Clinical Pharmacokinetics and Laboratory
This course will cover the methods of applying pharmacokinetics for the safe and effective therapeutic management of individual patients.

375.517 Drug-receptor Interaction and Laboratory
This course will cover the concepts of receptors involved in physiological phenomena, theoretical and experimental classification of receptors, and handling processes such as the purification, characterization, and cloning of receptors with biological activities.

375.589 Topics in Transcriptomics
Transcriptional gene regulation is the major mechanism that controls gene expression in normal physiology as well as pathological conditions. In this course, transcriptomics in prokaryotes and eukaryotes including basal transcriptional machinery, transcription activator complexes, and chromatin remodeling complexes will be instructed. Experts in this field will be invited to review the recent trends in transcriptomics and to discuss the current topics and advanced experimental approaches in gene regulation. Also students are encouraged to present and discuss hot topics in this field in the class.

375.618 Biochemical Pharmacology
This course will take a theoretical approach to the study of the cellular and sub-cellular actions of drugs and the relationship between these actions and the pharmacological properties of medicinal agents in intact organisms.

375.620 Neuropharmacology and Laboratory
This course will cover the concepts of the role of the nervous system in controlling biological activities via the central or peripheral nervous system, the mechanisms through which each biological function is controlled by the nervous system, and the experimental methods to test these issues.

375.668 Topics in Molecular Pathophysiology
The molecular pathophysiology is the study, which elucidates disease process at the molecular level and explains the sequence of events in the response of the cells or tissues to etiologic agent by means of interaction with molecules. This course introduces the recent research trends classified according to their main theme and presents pathophysiological understandings of disease.

375.669 Phenomics of Model of Organisms
The discovery of genetic data of Model organism opens the systematic phenotype identification of organisms. Especially, phenotype of model organisms, including genetically-- engineered mouse or mutants, is essential for the construction of a great biological atlas of gene map. This course was built on the conceptual basis of "the diagnostic clinic for mice" and also presents the understandings of the comprehensive systematic analysis of genetically engineered mouse.

375.670 Topics in Protein Therapeutics Development
Biopharmaceutics refer to macromolecules derived from living organisms, therapeutic proteins generally taking the most of the part. At present, high market growth rate of such therapeutic proteins is attracting many companies to thrust into the market. In this subject, the characteristics of the development of recent protein therapeutics are summarized, and the series of developing process is discussed in industrial, academic, and regulatory point of view.

375.695 Cardiovascular Pharmacology and Laboratory
This course will consist of a consideration of the nature of the normal homeostatic regulation of the cardiovascular system and of its modification by drugs, and of the sites and characteristics of drug actions affecting the cardiovascular system.

375.721 Topics in Cellular Pathophysiology
The fundamental structures and functions of cells in higher organisms and the molecular mechanisms of intracellular signal transduction pathways which connect extracellular stimuli to gene expression will be instructed. Also, recent advances in cell physiology and the related human diseases and therapy will be introduced and discussed.

375.786 Advanced Pharmacokinetics
This course will cover the basic and latest topics in pharmacokinetics.

375.787 Membrane Potentials & Ion Channels
The membrane potential is the potential difference across the membrane, which is caused by the activities of various ion channels. In addition to controlling internal millieu such as osmosis, volume, and signal transduction, the membrane potential determines the excitability of muscle and neurons. Ion channels are excitable elements in the cell membrane and determine the electrical signals of muscles and nerves. Because of the latest advances in biochemistry, molecular biology, and electrophysiology, the genetic information on and structures of the ion channels are largely known. In this course, the definition of the membrane potential with a concomitant introduction to classical biophysical experiments will be discussed. The properties, genetic codes, structures, and functions of ion channels in relation to various diseases will also be explored.

375.813 Molecular Pharmacology
The course of molecular pharmacology provides information on drug action or selective toxicity at the molecular level. Molecular Pharmacology includes the studies of drug receptors, drug-enzymes, molecular biology of drug metabolism, signaling pathways, proteinnucleic acids interaction, and drug-induced gene regulation. Students are encouraged to discuss components of biological experimentation and recent reports on molecular pharmacology. This course is offered to the students in Ph.D. and M.S. programs.

802.901 Advanced Physiology I
This is a systemic study of the functions of various body systems, such as cardiovascular, gastrointestinal, respiratory and endocrine systems. Lectures emphasize various mechanisms involved in maintaining a proper internal environment for the normal existence of body.

Courses in Pharmaceutical Health Science Major

375.518 Advanced Hygienic Chemistry
This course will review the latest literature on hygienic chemistry, with an emphasis on the disposition of xenobiotics, toxic mechanism, and biological self-defense mechanism.

375.523 Industrial Toxicology
This course will introduce the general principles of industrial toxicology. Topics will cover the toxicity of air-borne industrial chemicals such as solvents, gases, and particulates. Special emphasis will be placed on industrial hygiene practice.

375.622 Drug Induced Disease
This course will cover the diseases that result from extended drug treatment and misuse from theoretical and practical viewpoints.

375.623 Clinical Pharmacy Clerkship 1
This course will consist of field practice in selected hospitals that possess in-patient care facilities so as to provide students with a chance for practical experience as future clinical pharmacists.

375.624 Clinical Pharmacy Clerkship 2
This course will consist of field practice in selected hospitals that possess in-patient care facilities so as to provide students with a chance for practical experience as future clinical pharmacists.

375.625 Environmental Hygiene and Laboratory
In this course, students will survey and conduct experiments on the current state of environmental elements such as air, water, and earth as well as the physical and chemical substances in these elements.

375.629A Pesticide Toxicology 1
This course will cover the latest developments in insect physiology and biochemistry. Also, it will examine the mode of action of major pesticides in both insect and vertebrate systems.

375.711 Biological Self-defense Mechanism
The course will review several important current issues including cellular defense mechanisms in free radical toxicology.

375.716 Methods in Biological Safety Evaluation
This course aims at providing students with a better understanding of the fundamental physiological mechanisms for biological safety evaluation.

375.718 Molecular Toxicology
In the course of molecular toxicology, students are learning about the toxicology of xenobiotics at the molecular level. In this course, metabolic activation (biotransformation) of xenobiotics, interaction of xenobiotics with genes, gene expression and signal transduction as well as the health effects caused by the series of the events.

375.719 Clinical Pharmacogenomics
Recently, the rapid development of pharmacogenomics have provided extensive information regarding on the genetic background on the wide inter-individual variation of drug responses, which is expected to lead to the era of personalized pharmacotherapy. Pharmacogenetics is a science that is interesting to the inherited variants of genes related to pharmacokinetics (drug metabolizing enzymes, drug transporters etc.) and pharmacodynamics (receptor, ion channel, target enzyme etc.), which are associated to the susceptibility of an individual to the higher risk of ADR or therapeutic failure. In this course, students will learn the role of pharmacogenomics in relation to wide inter-individual variation of drug disposition and to the possible contribution to the personalized pharmacotherapy.

375.720 Clinical Trial Methodology
Clinical pharmaceutical trial is a research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments. The importance of clinical pharmaceutical trial in drug approval as well as bioequivalence of generic drug and the acquisition of foreign currencies through multi-national pharmaceutical trial caused social attention. In this course, students will learn the fundamental concepts and how to design, develop and evaluate all phases of a clinical pharmaceutical trial.

375.808 Free Radicals in Biology and Medicine
Free radicals such as oxygen and carbon-centered radicals are generated endogenously and/or exogenously in humans. Due to their high reactivity with macromolecules including DNA, proteins, and lipids, they can damage cells and tissues, finally leading to various chronic degenerative diseases. This course will introduce the sources of free radicals generated in the cells and recent technology to detect free radicals, and provide a number of examples for toxic insults resulting from free radicals.

375.810 Advanced Pharmacotherapy
This is a course on pharmacotherapy for more advanced disease states. It will focus on the considerations and precautions required for the proper selection, dosage, and monitoring of drugs and the recognition of clinically significant, efficacious, and/or toxic drug interactions, in order to provide safe, effective, and rational drug therapy based on the current medical and pharmacy literature. Emphasis will be placed on problem-solving by analyzing actual patient cases.

375.815 Patient Education
Students will acquire knowledge needed for patient education with focuses on drug products, drug regimen, side effects, cautions, dietary considerations, etc.

375.816 iv Admixture of TPN and Clinical Application
Students are exposed to the preparation of aseptic parenteral nutrition products while considering their safety, stability, and drug interactions. This course will focus on nutritional assessment, pediatric/adult nutritional considerations, drug-nutrient interactions, enteral nutrition, and their proper monitoring.

375.817 Topics in Drug Information
This course introduces students to drug information sources and how to access them, systematic drug literature searches, and how to answer drug information questions. The course emphasizes clinical services, focusing on actual experience in literature retrieval, analysis, and dissemination of drug information.

375.818 Pediatric Pharmacy
This is a course on the application of clinical principles of pharmacology, biopharmaceutics, and toxicology to optimize disease management for pediatric patients.

375.819 Geriatric Pharmacy
This is a course on the application of clinical principles of pharmacology, biopharmaceutics, and toxicology to optimize disease management for geriatric patients.

375.820 Seminar in Clinical Pharmacy
Students are involved with discussions and practical sessions that enhance their understanding and skill levels in selected areas of clinical practice. Students enhance their verbal presentation, communication, writing, and problem-solving skills. They also work on the critical analysis of data and the provision of care through a weekly conference and projects.

375.821 Topics in Pharmaceutical Affairs
This course has students analyzing the practice and implementation of pharmaceutical care. Students confront their assumptions about the pharmacy profession, pharmacy practice, and pharmaceutical care. The course includes discussions, guest speakers, intensive literature searches, and evaluations.

375.822 Drugs in Society
This course covers the following topics: cultural foundations of pharmacy; development of the present state of pharmacy practice; the role of the pharmacist as a health practitioner in relation to other health practitioners; and the identification of factors (health policy, regulation, economics, research and development, promotion) that affect individual responses to drug therapy.

375.823 Pharmaceutical Economics & Policy
This course covers the following topics: economic analysis of the pharmaceutical sector of health care systems; problems of pricing production and distribution of pharmaceuticals; and domestic or international policy issues relevant to price and access of pharmaceuticals.

375.834 Research Methods in Social & Administrative Pharmacy
This course aims to provide the practical knowledge and techniques for economic evaluation. Students learn modeling techniques as decision-analysis and Markov modeling, and various methods and computations of health state preference elicitation and willingness-to-pay. This course helps students to enhance basic skills of literature collect and computer programming in economic evaluation. This course is run as a lecture and seminar with student's project involving pharmacoeconomic study.

375.835 Introduction to Carbohydrate-based Drugs
This course will cover methods and research design as related to pharmacy administration. It will combine an overview of research methods and more in depth examination of specific research methods that may be used to complete research done in the field.

375.837 Clinical Pharmacometrics
Pharmacokinetics is the study of mathematically quantifying a drug's pharmacodynamic/ pharmacokinetic phenomenon. The existing method of predicting a drug's efficacy or side effect is based on the plasma concentration of a drug. However, it is becoming evident that the relationship between plasma concentration and the actual efficacy or side effects of a drug is imperfect. This has brought into light the concept of pharmacometrics, which is the combined science of pharmacodynamics and pharmacokinetics, to yield a more precise and refined result. Pharmacometrics encompassess each area of Population PK, PK/PD modelling and simulations; making it have a wide range of uses. Through this course, students will get a deeper understanding of pharmacometrics and the practical skill to apply it in their research. The ultimate purpose of teaching clinical pharmacometrics is to educate each student to be able to produce a research outcome that indicates an optimum dosage and directions of drugs for an "individualized pharmacotherapy".

Courses in Pharmaceutical Chemistry Major

375.571 Advanced Pharmaceutical Chemistry 1
This course will cover the chemical bond theory and the chemical structural theory. It will take an instructional approach to carbonium ion, carbanion, radical, benzene, and nitrene.

375.573 Chemistry of Chemotherapeutic Agents 1
This course will cover the development of new chemotherapeutics and theoretical approaches to the relationship between chemical structures and pharmaceutical actions (anticancer agents, sulfa drugs, and fungicidal drugs) in pharmaceutical synthesis, anticancer agents, and antibiotics.

375.579 Stereochemistry 1
This course will introduce sterochemical concepts including the characteristics of chemical bonds, steroisomerism and absolute configuration, asymmetric carbon and enantiomer, configurational notations, and structures of molecules and symmetry.

375.678 Stereochemistry 2
This course will cover the application of modern stereochemical concepts to the preparation of optically active compounds including the resolution of racemic compounds, stereoselective reactions, asymmetric synthesis, stereochemistry of substitution reactions, sterochemistry of pericyclic reactions, stereochemistry of double bonds, and optically active compounds without asymmetric carbons.

375.771 Chemistry of Chemotherapeutic Agents 2
This course will consist of instruction on the synthesis and chemistry of antimicrobial chemotherapeutics such as β-lactam antibiotics and aminoglycoside antibiotics.

375.772A Advanced Medicinal Chemistry 1
The purpose of this course is to explain the mode of action of drugs at the molecular level including receptor, enzyme and DNA, and to introduce the concept of pharmacophore, bioisosteres, quantitative structure activity relationship and molecular modeling in order to understand the structure activity relationship of drugs. The contents include drug discovery and development, receptor ligands, enzyme inhibitors, DNA-interactive agents, drug metabolism, prodrugs and drug delivery systems.

375.774 Advanced Pharmaceutical Chemistry 2
The applications to organic synthesis, reaction mechanisms, and recent achievements of organic transition metals will be covered in this course. The course will also include topics on recent organic reactions.

375.789A Advanced Medicinal Chemistry
This course covers the up-to-date methods and technology related to lead discovery and optimization for new drug development and provides the individual seminars with the topics of updated information about new drug development based on diseases. The contents of lecture include the rational drug design and molecular modeling and the topic of seminar covers the update information of new drug development including CNS diseases, cardiovascular and metabolic diseases, inflammatory diseases, and cancer and infectious diseases.

375.791 Physical Organic Pharmaceutical Chemistry 1
The general organic reaction mechanisms will be studied in this course through an introduction to the physical, organic, and chemical properties of organic reaction such as substitution and elimination reactions.

375.792 Physical Organic Pharmaceutical Chemistry 2
New organic reaction mechanisms and their applications will be studied in this course through an introduction to the physical, organic, and chemical properties of new organic reactions.

375.793 Advanced Organic Pharmaceutical Chemistry 1
The structural features and preparation of olefin and 3-9 membered carboncycles will be discussed in this course. In addition, their synthetic applications to bioactive molecules including natural products will be discussed.

375.794 Advanced Organic Pharmaceutical Chemistry 2
The structural features and preparation of olefin and 3~9 membered carboncycles will be discussed in this course. In addition, their synthetic applications to bioactive molecules including natural products will be discussed.

Courses in Pharmaceutics Major

371.688 Biomedical Biomaterials
The purpose of this course is to introduce students to biomaterials used for drug delivery systems and medical devices so that they can understand the role and function of materials used in the biomedical field. In particular, students will learn about such biopolymers as proteins and polysaccarides, as well as synthetic polymers such as polyethylene glycols. Materials to be taught will be separated based on characteristics and structure. For characteristics, biodegradable polymers, water soluble polymer and hydrogels will be introduced, and structurally linear polymer and crosslinked polymers will be introduced. The course will deal with the structure of biomaterials, and interaction between matter and drugs. Using examples, students will learn to analyze function of materials, which is to decrease toxicity and increase drug efficiency. In particular, the course will focus on the material characteristics of implantable materials and their interactions with biological systems upon contact. Through this course, students will learn to predict and solve problems in developing drug delivery materials with respect to possible side effects or toxicity from the perspective of materials.

371.689 Advanced Macromolecular Drug Delivery
The purpose of this course is to explore the problems involved with administration of macromolecular drugs; through analyzing and solving such problem, students will understand problem solving techniques using drug delivery system and build on knowledge to create new technologies. Macromolecular drugs to be dealt with in this course refer to protein and polysaccharide drugs and DNA used in treatment of diseases. For protein drugs, Students will learn about drug delivery systems using chemically/physically combined technologies, manipulative technologies, formulation and device technologies. For polyssacharide drugs, students will learn about non-invasive delivery using chemical derivatives, and for genetic drugs, viral or non-viral vector systems. Furthermore, students will learn about cell delivery technology using the DNA manipulative cell technology. The course focuses on the understanding of the basic principles of the above and the analysis of recent technologies being researched in the field.

375.555 Advanced Pharmaceutics 1
This course will consist of lectures on theoretical methodology and the selection, application methods, and timed release of preparations in order to evaluate, guarantee, and enhance the quality of drugs.

375.556 Advanced Physical Pharmacy 1
This course presents the following major topics; 1) an overview of molecular structure and molecular interaction of drugs. 2) The application of spectroscopic methods and X-ray crystallography to the pharmaceutical system. 3) General principle of electrolytes and solution system and dispersion system in pharmacy.

375.557 Pharmaco-biophysics
This course will include various physicochemical characteristics that can be studied though pharmacologically active compounds, various organs, and bioavailable substances.

375.559 Advanced Dispersion System
This course will study dispersion systems including small particle technology, interfacial phenomena, and electrokinetic and rheological properties of materials in colloidal and coarse dispersions.

375.561 Preformulation and Formulation of Pharmaceuticals
The aim of this course is to increase the understanding of the students to the area of preformulation and formulation technologies of pharmaceuticals including chemical and biological drugs. For chemical drugs, the physichochemical preformulation and route-specific formulation technologies will be covered. For biological drugs such as antibodies and nucleic acids, the injectable formulations and noninvasive formulations will be emphasized. Moreover, besides conventional pharmaceutical formulations technologies, the cutting-edge technologies applied to protein, nucleic acid, and cell-based pharmaceuticals will be introduced.

375.657 Advanced Pharmaceutics 2
This course will cover the factors relevant to the preformulation of pharmaceuticals. Topics will include the solubilization, dissolution, absorption, and excipients of active ingredients.

375.659 Advanced Physical Pharmacy 2
The study of the thermodynamic properties of drugs in solutions and the application of thermodynamics and kinetics to the decomposition and stabilization of medical agents will be included in this course.

375.660 Advanced Industrial Pharmacy
The topics to be discussed in this course are the principles and production schemes of new drug delivery systems.

375.809 NMR in Pharmacy
The theory and application of NMR spectroscopy concerning the structure determination of biological compounds (proteins and nucleic acids) will be studied in this course.

375.824 Topics in Drug Transporters in Biological Membranes
This course includes topics relevant to the drug transport phenomenon, which affects absorption, distribution and excretion. Characteristics of transporters, methodologies in such studies, and practical application will be discussed and updated regularly.

375.825 Topics in Tissue Specific Drug Transport
Various strategies for tissue-specific drug targeting will be discussed. The strategies that utilize the characteristics of transporters will be the primary focus for the course discussion. Particular emphasis will be on tissues that interface polarized epithelial cells such as brain and kidney cells.

375.826 Topics in Pharmacokinetic Drug Interaction
A drug interaction generally refers to a modification of the expected drug response in the patient, due to the exposure of the patient to another drug or substance. Some unintentional drug interactions produce adverse reactions in the patient, whereas some drug interactions may be intentional to provide an improved therapeutic response or to decrease adverse drug effects. Drug interactions may include drug-drug interactions, food-drug interactions or chemical-drug interactions, such as the interaction of a drug with alcohol and tobacco. In this lecture, the risk of a drug interaction in association with multiple drug therapy, multiple prescribers, poor patient compliance, and patient risk factors will be discussed. Screening for drug interactions, significance of the interaction, mechanisms of drug interactions during the processes of absorption, metabolism, disposition, biliary and/or renal excretion will also be discussed using appropriate examples.

375.827 Topics in Pharmacokinetics
Pharmacokinetics is the study of the time course and concentrations of drugs in biological fluids, tissues, and excreta. Physiological, biochemical, and mathematical knowledge will be applied to model the temporal relations of drug concentrations. Topics will include kinetic characterizations relevant to the processes of absorption, distribution, metabolism, and excretion. Updated literature information will be evaluated in relevant topics.

375.828 Topics in Pharmacokinetics Analysis
This course covers the estimation of kinetic parameters. Particular attention will be paid to the statistical estimation of the parameters using computers and nonlinear least square methods. The estimates will be applicable in 1) understanding the kinetic processes; 2) prediction of dose and dosing rates for optimal clinical response; and 3)ultimate development of safe and effective therapeutics.

375.829 Topics in Biopharmaceutics
The course will discuss topics in pharmaceutics including factors that affect the absorption, distribution, metabolism, and excretion of drugs.

375.830 Topics in Experimental Biopharmaceutics
This course will include topics such as the routes of administration, distribution, and disposition of pharmaceuticals and bioavailability. Particularly, the methodologies in the literature relevant to these topics will be discussed and evaluated.

375.831 Topics in Bioactives Delivery Systems
This course covers the methods of preparation, evaluation and application of delivery systems, as well as physicochemical interactions between bioactives and delivery systems, and physiological considerations of delivery systems.

Courses in Natural Products Science Major

371.514 Natural Medicines
This course is intend to provide the students with the broad range of knowledge concerning complimentary and alternative medicine (CAM). The potential benefits and the safety issues of CAM are to be discussed. The problems concerning the drug interactions among CAM and with conventional therapies are also to be discussed. The recent research progress on the inter-complementary effects of CAM and conventional medicines are to be reviewed with examples.

375.836 Introduction to Carbohydrate-based Drugs
Carbohydrate is one of the biopolymers with protein and nucleic acid in the body. Nowadays it draws a lot of attention owing to diverse roles including signaling bridge, receptor binding, and cell-cell communications. This lecture will be focused on the structure, analysis, polysaccharides from natural products, plant glycobiology, microbial glycobiology, animal lectins, glycosylation and diseases, and carbohydrate therapeutics.

821.510 Special Research in Chemistry of Natural Products
This lecture is designed to help students interpret spectral data for the identification and characterization of the structures of natural compounds obtained through fractionation, isolation, and purification.

821.511 Natural Products Chemistry
This course provides a comprehensive and balanced introduction to natural products. This course builds upon both fundamental chemical principles for natural products and a wealth of diverse secondary metabolites, and guides the graduates to acquire or expand their knowledge in the field of natural products chemistry.

821.512 Separation Techniques in Bioactive Natural Products
Principles and applications of modern separation methods necessary for the isolation of biologically active agents will be studied. It is recommended that students take Natural Products Chemistry and Biochemistry before taking this course.

821.520 Special Research in Biological Functions of Natural Products
This course is designed to provide students with information on existing methods and experimental techniques concerning models for searching biological activities including physiological, pharmaceutical and toxic activities. The contents include establishing new models for searching activities, and their applications.

821.521 Natural Products Biochemistry
This course will cover the following topics: understanding of molecules within cells; interactions between cells that allow for the construction of multi-cellular organisms; concepts and processes of molecular cell biology; gene control pathways; understanding of gene control during development and disease states; experimental tools that allow the study of living cells and organisms; and analyzing DNA and protein sequences. New discoveries and new methodologies covered are bioinformatics, DNA chip microarray technology, apoptosis, and signaling pathways. This course will demonstrate the dynamic nature of science and prepare the students not only to engage actively in scientific research and teaching but also to become educated members of a public that is increasingly asked to deal with complex issues such as environmental toxins, genetically modified foods, and human gene technology.

821.522 Natural Products Pharmacology and Toxicology
The course provides basic knowledge on general pharmacology related with natural products and traditional Chinese herbs. Students learn the following: interaction of receptors with drug molecules; physiological and anatomical structures of human cells, tissues and organs; and pharmacokinetics on natural products' absorption, distribution, metabolism and elimination. Additional focuses of the course will be toxicological aspects of natural constituents derived from herbal materials and screening methodologies of toxic effects.

821.523 Biological Functions of Natural Products
Basic chemical, biochemical, and pharmacological aspects of biologically active compounds will be studied in this course.

821.531 Natural Resources
The general uses and economic values of important natural resources will be reviewed to obtain overall ideas on the history and processes in the development of natural products. Natural resources with potential uses and the issue of under development are also discussed to accumulate the comprehensive knowledge on the development of natural products.

821.612 Topics in Natural Products Chemistry
This course provides expanded coverage of many topics on natural products chemistry. This course focuses on information on possible leads to new natural products, such as screening methods, and the surveys on modern HPLC hyphenated techniques or NMR methods in structure elucidation.

821.624 Natural Products Biotechnology
In recent years, there has been a heightened public awareness of the fast-growing field of biotechnology. Natural products biotechnology covers an explanation of the genetic foundation of biotechnology known as the tools approach. The ability to manipulate the genetic make-up of organisms has led to explosive progress in all areas of this field. This lecture examines the fundamental principles and facts that underlie current practical applications of various organisms, describes those applications, structure and biosynthesis of the biologically active metabolites, and examines future prospects for related technologies.

821.625 Topics in Natural Products Biochemistry
This lecture concentrates on the relationship between active natural compounds' function toward cell membrane and various functions of membrane proteins & enzymes for the understanding of the biological activity of active compounds at the level of biological cell membrane.

821.626 Topics in Natural Products Pharmacology and Toxicology
It is recommended that students who take this course have prior knowledge of general pharmacology, physiology, biochemistry and anatomy. Knowledge of individual natural drugs and their constituents on pharmacology and toxicology will be emphasized. In addition, pharmacology, toxicology and drug-interaction of traditional herbal drugs such as traditional Chinese drugs will be studied as well. By taking this course, students will learn how to develop useful natural drugs and related products such as dietary supplements, and functional cosmetics.

821.627 Topics in Biological Functions of Natural Products
Recent articles on special topics in Natural Products Science will be discussed in this course.

821.632 Topics in Natural Resources
In order to learn about the uses and developments of useful natural products, various groups of natural resources will be discussed in depth, in regards to their characteristics and processes of development. Current approaches to the development and research of natural resources will be also discussed.

821.642 Topics in Natural Products Information
In this class, students will search the Internet for information on the natural products industry, regulatory agencies, and natural products sciences. Throughout the course, students will learn database construction techniques using HTML. Based on such basic information technology, all students will have access to information on regulatory agencies over the world, such as the American FDA, and other agencies in the EU, Japan, China, Korea, etc. Students will first learn about regulations regarding the registration process and requirements of various natural products like natural drugs, dietary supplements, functional cosmetics and related products. Then, the students will practice the registration process with a model item of their own to obtain registration permission. Through on-line training, students will construct their own databases on natural products information.

821.711 Structure Elucidation of Natural Products
The development of spectroscopic methods has enabled the structure elucidation of secondary metabolites. The identification of natural products by spectrometry is greatly facilitated by ready access to reference spectra. Therefore, this course provides many exercises for structure elucidation of natural products by spectroscopic data obtained from reference spectra.

821.713 Natural Products Synthesis
This course covers selected topics including both the partial and total synthesis of natural products. A wide-ranging survey of organic syntheses with an emphasis on important functional group transformations and carbon-carbon bond-forming reactions are provided. The course also includes retro-synthetic analysis and the method for selective synthesis of optically active compounds and heterocycles.

821.715 Marine Natural Products Chemistry
Marine organisms produce a wide variety of biologically active and structurally unique metabolites. This course focuses on the chemical, biological, and pharmacological features of marine natural products compared to those derived from terrestrial organisms. Theoretical and experimental approaches to these compounds are also covered, as well as their pharmaceutical and biotechnological potentials.

821.716 Topics in Natural Products Synthesis
Biologically active natural products are rich sources of medicines. This course will provide advanced knowledge of natural products focusing on their structure, chemistry, biological activity, and synthesis. The focus will be on the chemical synthesis of biologically active natural products with complex structures. Topics include retro-synthetic analysis and designing synthetic pathways using recent chemical databases and journals.

821.721 Cell Function Regulations from Natural Products
This course concentrates on a small number of organisms and the critical experiments that have advanced our understanding of the cell cycle. The topics include the following: origin of the different experimental approaches to the cell cycle: principles of cell cycle regulation, especially focusing on the roles of the cyclin dependent protein kinases; their contribution to our current picture of cell growth and division; how different organisms have specialized in regulating particular aspects of cell cycle control, resulting in the emergence of a great plethora of proteins that govern cell cycle progression; and the question of cancer and other important medical problems. This course also focuses on the field of "signal transduction", which has revealed almost unimaginable diversity and complexity within large families of proteins involved in the production and destruction of second messenger molecules, and information transfer via kinase cascades and their associated regulatory proteins.

821.731 Taxonomy of Economic Plants
In this course, students are introduced to general classification systems on organisms with an emphasis on economically important biological resources. Basic concepts of biological classification will be discussed in detail, such as rules on biological nomenclature, scientific names, characters, and phylogeny. In addition, organisms with important economic value will be introduced to provide general understanding on important natural resources.

821.734 Studies in Bioactive Natural Product Evaluation
The purpose of this course is to study the principle and biochemical and pharmacological mechanisms of action of bioassay systems in the identification of the biologically active natural products with potential pharmacological effects.

821.735 Microbial Secondary Metabolite Chemistry
Microbial secondary metabolites have been platforms of drug discovery and provided natural products with diverse structures and biological activities. Microbial secondary metabolites also mediate important chemical interactions between organisms in nature. This course discusses chemical and biological characteristics of natural products derived from microorganism by classifying their structures. This course also teaches the pharmacological applications and the fundamental roles of microbial natural products.

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